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IRCT2016082829556N1 IRCT 2016-10-10 Vice chancellor for research of Kashan University of Medical Sciences and Health Servisces,Kashan Aspirin as an augmenting to Sertraline for treating major depressive disorder, a randomized double blind placebo controlled clinical tria Aspirin as an augmenting to Sertraline for treating major depressive disorder, a randomized double blind placebo controlled clinical trial 2016-09-01 anticipated 100 Complete https://irct.ir/trial/23726 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Other design features: using Table of random numbers. 2 Major Depressive Disorder. Intervention 1: Sertraline as a serotonin reuptake inhibitor with 150mg daily dosing for 8 week and is production of Dr Abidi pharmacy. and Aspirin (acetyl salysilic acid) 80mg two times per day for 8 week that is production of Dr Abidi pharmacy. Intervention 2: Sertraline as a serotonin reuptake inhibitor with 150mg daily dosing for 8 week and is production of Dr Abidi pharmacy + placebo for 8 week.
public Hossein Fahimi
Kargarnejad Hospital, Kashan University of Medical Sciences and Health Services, Pezeshk Blvd, 5th of Qotbe Ravandi Blvd, Kashan
Kashan Iran (Islamic Republic of) +98 31 5531 4908 hossein1fahimi@gmail.com Kashan University of Medical Sciences and Health Services scientific Hossein Fahimi
Kargarnejad Hospital, Kashan University of Medical Sciences and Health Services, Pezeshk Blvd, 5th of Qotbe Ravandi Blvd, Kashan
Kashan Iran (Islamic Republic of) +98 31 5531 4908 hossein1fahimi@gmail.com Kashan University of Medical Sciences and Health Services Iran (Islamic Republic of) Inclusion criteria: patients with major depressive disorder according to DSM-VI, both gender, and aged between 40 and 80 years old, Consent to participate in the study by completing the informed consent form, Having risk factors for coronary heart disease or stroke. Exclusion criteria: Depression due to physical illness or drug use, A history of gastric ulcers and contraindications for taking aspirin, pregnant women, History of alcohol and substance abuse within 6 months prior to the beginning of the study, positive history of mania, mental retardation, psychosis, using another antidepressant within 4 weeks prior to starting ASA, Candidates for other treatments such as ECT for depression. 40 years 80 years Both F32 Depressive episode Treatment - Drugs Placebo Sertraline as a serotonin reuptake inhibitor with 150mg daily dosing for 8 week and is production of Dr Abidi pharmacy. and Aspirin (acetyl salysilic acid) 80mg two times per day for 8 week that is production of Dr Abidi pharmacy. Sertraline as a serotonin reuptake inhibitor with 150mg daily dosing for 8 week and is production of Dr Abidi pharmacy + placebo for 8 week Depression. Timepoint: baseline,4 week, and8 week. Method of measurement: Beck Depression Inventory. Vice chancellor for research of Kashan University of Medical Sciences and Health Servisces,Kashan Approved 2015-06-01 Ethics committee of Kashan University of Medical Sciences and Health Services Pezeshk Blvd, 5th of Qotbe Ravandi Blvd,Vice chancellor for research of Kashan University of Medical Sciences and Health Services Kashan Iran (Islamic Republic of)