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IRCT138812222602N3 IRCT 2010-03-13 Iran University of Medical Sciences Effect of Dark chocolate consumption in hypertensive type 2 diabetes Effect of dark chocolate consumption on ApoB, ApoA-1, lipid profile, hsCRP, glycemic control and blood pressure in type 2 Diabetec patients with hypertention. 2010-09-23 anticipated 70 Complete https://irct.ir/trial/2374 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Supportive. 3 Type 2 Diabetes. Intervention 1: control: 25 gr of white chocolate for 8 weeks. Intervention 2: intervention: 25 gr of dark chocolate for 8 weeks.
public Dr. Shahriar Eghtesadi
School of Health, Alvand Ave, Arjanteen Square
Tehran Iran (Islamic Republic of) +98 21 8877 9118 egtesadi@yahoo.com School of Health, Iran University of Medical Sciences scientific Dr. Shahriar Eghtesadi
School of Health, Alvand Ave, Arjanteen Square
Tehran Iran (Islamic Republic of) +98 21 8877 9118 egtesadi@yahoo.com School of Health, Iran University of Medical Sciences Iran (Islamic Republic of) Inclusion criteria: Being volunteer or wishing to attend, 35-65 y old, diagnosed with type 2 diabetes for at least 1 year (FPG ≥ 126 mg/dl or 2hPG ≥ 200 mg/dl), BMI ≤ 40 kg/m2, HbA1C < 9%, Blood pressure ≥ 130/80 mmHg and no regular use of any drugs or supplements with antioxidative (β-carotene, vitamins C or E) or lipid-lowering properties. Exclusion criteria: Allergy to chocolate, Taking insulin, Smoking cigarette, drinking alcohol or drug abuse, congestive heart failure, malignancies, chronic kidney , hepatic and thyroid diseases , severe cardiac arrhythmias, inflammation following vegetarian or weight-reducing diet 2 months before the study ,Changing medication dosage or physical activity level 2 mo before or during the study. 35 years 65 years Both E11 Diabetes mellitus Other Other control: 25 gr of white chocolate for 8 weeks intervention: 25 gr of dark chocolate for 8 weeks Decrease Low Density Lipoprotein. Timepoint: 8 weeks. Method of measurement: Laboratory kit. Decrease blood pressure. Timepoint: 8 week. Method of measurement: sphygmomanometer. Decrease Apo B. Timepoint: 8 weeks. Method of measurement: immunoturbidimetry. Increase ApoA-1. Timepoint: 8 weeks. Method of measurement: immunoturbidimetry. Decrease Triglyceride (TG). Timepoint: 8 weeks. Method of measurement: Laboratory Kit. Decrease Fasting Blood Sugar (FBS). Timepoint: 8 weeks. Method of measurement: Enzymatic. Decrease high sensitivity C-reactive protein (hs-CRP). Timepoint: 8 weeks. Method of measurement: Immunoturbidimetry. Decrease HbA1C. Timepoint: 8 weeks. Method of measurement: Laboratory Kit. Iran University of Medical Sciences Approved 2010-07-18 School of Health, Iran University of Medical Sciences Alvand Ave, Arjanteen Square Tehran Iran (Islamic Republic of)