IRCT201708292604N3 IRCT 2017-09-18 Yazd Reproductive Sciences Institute, Shahid Sadoughi University ٍٍEffect of GnRH-a in endometrial preparation for frozen-thawed embryo transfer cycles in patient with repeated implantation failure. Effect of GnRH-a in endometrial preparation for frozen-thawed embryo transfer cycles in patient with repeated implantation failure. 2017-08-16 anticipated 67 Complete https://irct.ir/trial/2385 interventional Randomization: Randomized, Blinding: Not blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: Patients are divided into two groups of 34 patients according to permutation block method of control and intervention. Therapeutic tasks within the blocks are determined in such a way that they are random, but the desired allocation ratio is achieved in each block. There are 8 blocks in each,is 8 numbers in order to reaches sample size to 64 and one block of 4 is considered. Generate random codes using random block allocation method which will be generated with the help of Random allocation software version 1. The first person eligible to enter the study is given number one and so on until the last person eligible for number 67 is given.Using a table generated by random allocation software by number, individuals are placed in the control and intervention group. The output of Random allocation software version 1 is specified as A and B in the specified blocks, which describe the number of blocks and the number of patients in each block. 2-3 repeated implantation failure. Intervention 1: In case group , patients receive daily subcutaneous injections of 0.1 mg of GnRH-a( diphereline) starting from day 21 of previous cycles.The dose is reduce to 0.05 mg from the second day of cycle when daily oral estradiol valerate 6mg is also started.Daily vaginal progesterone 400mg twice daily is started when endometrial thickness is > 7.5 mm and GnRH_a is also stopped. Intervention 2: In control group oral estradiol 6mg daily is started from day 2 cycle without diphereline. Daily vaginal progesterone 400mg twice daily is started when endometrial thickness is > 7.5 mm. Yes - There is a plan to make this available What will be shared: participant data set able to be shared When: 2 months after publication To whom: Journal that published the results Conditions: A person/office that is legally in charge Where to obtain: Yazd Reproductive Sciences Institute 983538247085 saeideh_dashti@yahoo.com How to obtain: Submission of legal order Comments: