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IRCT201403242624N13 IRCT 2014-09-09 Vice chancellor for research ,Iran University of Medical Sciences. Labor induction A comparison between the effect of oral titrated solution of misoprostol and intravenous oxitocine for labor induction in term pregnancies. 2014-04-21 anticipated 80 Complete https://irct.ir/trial/2418 interventional Randomization: Randomized, Blinding: Not blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment. 2-3 Condition 1: cervical ripening. Condition 2: induction of labor. Condition 3: medical induction of labour. Condition 4: Delivery. Intervention 1: administration of oral titrated solution of misoprostol. 200 microgram misoprostol will be solved in 200 mili liter water, and 20 cc of this solution will be prescribed every 2 hours. ( maximum 60 micro gram). Intervention 2: infusion of 2.5 mili units oxitocine per minute that will be doubled every 15 minutes. Maximum dose of oxitocine is 60 mili units per minute.
public Maryam Kashanian
Molavi avenue, Molavi Cross.
Tehran Iran (Islamic Republic of) +98 21 5563 3244 maryamkashanian@yahoo.com Iran University of Medical Sciences scientific Maryam Kashanian
Molavi avenue, Molavi Cross.
Tehran Iran (Islamic Republic of) +98 21 5563 3244 maryamkashanian@yahoo.com Iran University of Medical Sciences Iran (Islamic Republic of) Inclusion criteria: age between 20-40 year old; reliable gestational age between 40-42 weeks; singleton pregnancy with cephalic presentation; BISHOP Score of more than 5; favorable pelvis. Exclusion criteria: parity of more than 3, blood pressure equal or more than 160/110 mmHg; abnormal NST and any sign of fetal distress; urine protein of more than 2 gram in 24 hours; suspicious for HELLP syndrome; poly hydramnios; probable macrosomia; any vaginal bleeding; history of any surgery on uterus; prostaglandin use during present pregnancy and beginning of spontaneous uterine contractions. 20 years 40 years Female O30 O61 O61.0 O80 Maternal care related to the fetus and amniotic cavity and possible delivery problems Complications of labour and delivery. Failed medical induction of labour Delivery Treatment - Drugs Treatment - Drugs administration of oral titrated solution of misoprostol. 200 microgram misoprostol will be solved in 200 mili liter water, and 20 cc of this solution will be prescribed every 2 hours. ( maximum 60 micro gram). infusion of 2.5 mili units oxitocine per minute that will be doubled every 15 minutes. Maximum dose of oxitocine is 60 mili units per minute. Number of deliveries during the first 24 hours. Timepoint: 24 hours. Method of measurement: Data sheets. Rout of delivery. Timepoint: ---. Method of measurement: data sheets. Uterine hyperstimulation. Timepoint: every 30 minutes. Method of measurement: monitoring of uterine contractions- tocography. Fetal distress. Timepoint: every 15 minutes. Method of measurement: fetal heart rate monitoring with tococardiography. Neonatal Apgar Score. Timepoint: minute 1 and 5. Method of measurement: data sheets. Number of deliveries during 6-12-18 hours from the beginning of induction. Timepoint: 6-12-18 hours from the beginning of induction. Method of measurement: data sheets. Duration of stage 1 , 2 and 3 of labor. Timepoint: end of stage 1 , 2 and 3 of labor. Method of measurement: data sheets. Interval between the beginning of induction up to the beginning of suitable contractions( 3 forceful contractions during 10 minutes). Timepoint: every 30 minutes. Method of measurement: data sheets. Indications for cesarean deliveries. Timepoint: during cesarean deliveries. Method of measurement: data sheets. NICU admission. Timepoint: After birth up to discharge. Method of measurement: data sheets. Duration of hospital stay for mother and baby. Timepoint: admission , discharge. Method of measurement: data sheets. Vice chancellor for research ,Iran University of Medical Sciences. Approved 2014-07-28 Ethic comittee of Iran University of Medical Sciences Hemmat highway, Chamran Cross Tehran Iran (Islamic Republic of)