IRCT20161023030455N2 IRCT 2018-08-06 Vice chancellor for research of Ahvaz Jundishapur University of Medical Sciences Department of Neuro Comparative efficacy of Duloxetine versus Gabapantin in patients with painful diabetic peripheral neuropathy Comparison the efficacy of Duloxetine versus Gabapantin in patients with painful diabetic peripheral neuropathy 2018-05-22 anticipated 104 Complete https://irct.ir/trial/24190 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: Four block, Blinding description: First, medicines are uniformed by a physician who is not involved in data collection or analysis. Then, these medicines are provided for researcher as medicines A and B. The complications of both medicines are explained for each of them. They are informed that they can receive any of the medications randomly and written consent is taken from them. Then, medicines are given randomly to patients by one who is responsible for data collection. Another person analyzes the data. 3 painful diabetic peripheral neuropathy. Intervention 1: The gabapentin group receives the gabapentin at a dose of 300 mg per day. Then, the dose of 300 mg increases every three days to reach 900 mg per day (300 mg three times per day) and treatment continues for up to 8 weeks. Intervention 2: Duloxetine (DLX) group: this group receives Duloxetine at dose of 30 mg per day before bedtime, and after one week, it increases to 60 mg per day if patient tolerates, and treatment continues for up to 8 weeks. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is more evalution