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IRCT2016102630475N2 IRCT 2017-02-09 Vice chancellor for research, Dentistry faculty, Tehran University Of Medical Sciences The effect of the propolis in oral wound healing - Clinical trial of comparison the effect of the propolis extract in combination with dressing without eugenol (Coe-Packtm) and Coe Packtm dressing in wound healing among patients undergoing crown lengthening surgery 2014-04-04 anticipated 36 Complete https://irct.ir/trial/24204 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment. 2-3 -. Intervention 1: Control group: The patients washed their mouth before surgery with chlorhexidine 0.12% for 30 seconds. Lidocaine 2% with epinephrine 1:100000 (Septodont, France) were prescribed for local anesthesia, too. After pulling over the flap and bringing out the granulation tissue, osteotomy with 13K/TG krikland periodontal chisel (Hu-Friedy Dental Instruments ,Chicago, USA), carbide burs (JOTA AG Rotary Instruments, Ruthi, Switzerland) under irrigation with saline solution until obtaining a distance of 3mm from bone crest to the most cervical portion of the cavity that was measured with a Williams periodontal probe (Neumar®). At the end of the procedure, a simple suture was performed with some silk thread (Supa, Iran). Time duration from the first cut to the last stitch for all the patients has been between 90–115 minutes. After surgery, the patients were divided into two randomized groups. In control group, the dressing was mixed with sterile spatula on a sterile glass plate according to the manufacturer’s instruction. Dressing was formed on the wound to adjust moderately. All the patients were educated to control the plaque with chlorhexidine 0.12% every 12 hours during 7 days and Ibuprofen 400 mg was prescribed every 6 hours, if necessary. Number and time of beginning the paregoric was recorded, too. All the patients received written and oral postoperative instructions. Some objective and subjective criteria were used to study the healing process. Intervention 2: Intervention group: The patients washed their mouth before surgery with chlorhexidine 0.12% for 30 seconds. Lidocaine 2% with epinephrine 1:100000 (Septodont, France) were prescribed for local anesthesia, too. After pulling over the flap and bringing out the granulation tissue, osteotomy with 13K/TG krikland periodontal chisel (Hu-Friedy Dental Instruments ,Chicago, USA), carbide burs (JOTA AG Rotary Instruments, Ruthi, Switzerland) under irrigation with saline solution until obtaining a distance of 3mm from bone crest to the most cervical portion of the cavity that was measured with a Williams periodontal probe (Neumar®). At the end of the procedure, a simple suture was performed with some silk thread (Supa, Iran). Time duration from the first cut to the last stitch for all the patients has been between 90–115 minutes. After surgery, the patients were divided into two randomized groups. After surgery, the patients were divided in two randomized groups. In trial group propolis extract was combined with coe-packtm. Then the dressing was mixed with sterile spatula on a sterile glass plate according to the manufacturer’s instruction. Dressing was formed on the wound to adjust moderately. Dressing in trial group was as the same as control group except adding 0.1 mm of 20% propolis hydroalcoholic solution (soren Tech Toos, Mashhad, Iran) per every 5 mm of dressing paste to the final dressing composition and placing that on the wound. This amount of propolis extract didn’t have any impact on the final dressing formidability. All the patients were educated to control the plaque with chlorhexidine 0.12% every 12 hours during 7 days and Ibuprofen 400 mg was prescribed every 6 hours, if necessary. Number and time of beginning the paregoric was recorded, too. All the patients received the written and oral postoperative instructions. Some objective and subjective criteria was used for studying the healing process.
public Atena Beiky
Dentistry faculty Of Tehran University Of Medical Sciences, Mahan St., Navab Blv.
Tehran Iran (Islamic Republic of) +98 21 5585 1131 Atena. beiki69@gmail.com Dentistry faculty, Tehran University Of Medical Sciences scientific Mitra Askari
Department Of Pathology, Dentistry Faculty, Tehran University Of Medicine Sciences, North Amir Abad St.
Tehran Iran (Islamic Republic of) +98 21 5585 1131 Askari_mitra@ymail.com Dentistry Faculty, Tehran University Of Medical Sciences Iran (Islamic Republic of) Inclusion criteria: bone removal scale in their surgery was between 1-2 mm; their surgical time duration lasted between 90-115 minutes and had been used from both of chisels and bur in their surgery; don’t have any systematically problem; no periodontal disease in the surgical site; no restriction on surgery; don’t need to the antibiotic prophylaxis during the surgery; don’t use the corticosteroids or hormone in the last 2 months. Exclusion criteria: when there is a problem in recording the patient’s information; smoking. no limit no limit Both - - Treatment - Drugs Treatment - Drugs Control group: The patients washed their mouth before surgery with chlorhexidine 0.12% for 30 seconds. Lidocaine 2% with epinephrine 1:100000 (Septodont, France) were prescribed for local anesthesia, too. After pulling over the flap and bringing out the granulation tissue, osteotomy with 13K/TG krikland periodontal chisel (Hu-Friedy Dental Instruments ,Chicago, USA), carbide burs (JOTA AG Rotary Instruments, Ruthi, Switzerland) under irrigation with saline solution until obtaining a distance of 3mm from bone crest to the most cervical portion of the cavity that was measured with a Williams periodontal probe (Neumar®). At the end of the procedure, a simple suture was performed with some silk thread (Supa, Iran). Time duration from the first cut to the last stitch for all the patients has been between 90–115 minutes. After surgery, the patients were divided into two randomized groups. In control group, the dressing was mixed with sterile spatula on a sterile glass plate according to the manufacturer’s instruction. Dressing was formed on the wound to adjust moderately. All the patients were educated to control the plaque with chlorhexidine 0.12% every 12 hours during 7 days and Ibuprofen 400 mg was prescribed every 6 hours, if necessary. Number and time of beginning the paregoric was recorded, too. All the patients received written and oral postoperative instructions. Some objective and subjective criteria were used to study the healing process. Intervention group: The patients washed their mouth before surgery with chlorhexidine 0.12% for 30 seconds. Lidocaine 2% with epinephrine 1:100000 (Septodont, France) were prescribed for local anesthesia, too. After pulling over the flap and bringing out the granulation tissue, osteotomy with 13K/TG krikland periodontal chisel (Hu-Friedy Dental Instruments ,Chicago, USA), carbide burs (JOTA AG Rotary Instruments, Ruthi, Switzerland) under irrigation with saline solution until obtaining a distance of 3mm from bone crest to the most cervical portion of the cavity that was measured with a Williams periodontal probe (Neumar®). At the end of the procedure, a simple suture was performed with some silk thread (Supa, Iran). Time duration from the first cut to the last stitch for all the patients has been between 90–115 minutes. After surgery, the patients were divided into two randomized groups. After surgery, the patients were divided in two randomized groups. In trial group propolis extract was combined with coe-packtm. Then the dressing was mixed with sterile spatula on a sterile glass plate according to the manufacturer’s instruction. Dressing was formed on the wound to adjust moderately. Dressing in trial group was as the same as control group except adding 0.1 mm of 20% propolis hydroalcoholic solution (soren Tech Toos, Mashhad, Iran) per every 5 mm of dressing paste to the final dressing composition and placing that on the wound. This amount of propolis extract didn’t have any impact on the final dressing formidability. All the patients were educated to control the plaque with chlorhexidine 0.12% every 12 hours during 7 days and Ibuprofen 400 mg was prescribed every 6 hours, if necessary. Number and time of beginning the paregoric was recorded, too. All the patients received the written and oral postoperative instructions. Some objective and subjective criteria was used for studying the healing process. Pain. Timepoint: 0,1,2,3,4,5,6 and 7 days after surgery. Method of measurement: Visual Analog Scale. Burning sensation. Timepoint: 0, 1,2,3,4,5,6 and 7 days after surgery. Method of measurement: Visual Analog Scale. Consistency of gingiva. Timepoint: 7th day after surgery. Method of measurement: palpation with a blunt instrument. Colour compatibility. Timepoint: 7th day after surgery. Method of measurement: Visual Analog Scale. Infection. Timepoint: 2nd & 7th days after surgery. Method of measurement: Clinical examination. Bleeding during probing. Timepoint: 7th day after surgery. Method of measurement: Probing. -. Timepoint: -. Method of measurement: -. Vice chancellor for research, Dentistry faculty, Tehran University Of Medical Sciences Approved 2016-01-02 Ethic Committee of Tehran University of Medical Science Ghods St., Keshavarz Blvd Tehran Iran (Islamic Republic of)