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IRCT2016122030475N3 IRCT 2017-02-02 Vice chancellor for research of International Campus, Tehran University of Medical Sienses. Effect of Propolis Extract on Chronic Periodontitis Patients Comparing The Effect of Propolis Extract and Chlorhexidine Mouthwash on Clinical Parameters and Salivary Level of Matrix Metalloproteinase 8 in Chronic Periodontitis Patients: A Randomized Controlled Clinical Trial 2017-01-20 anticipated 24 Complete https://irct.ir/trial/24205 interventional Randomization: Randomized, Blinding: Not blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Other design features: For the purpose of randomization, in every 10 patients, 10 envelops will be allocated; out of which, five containing propolis extract and the remaining five containing chlorhexidine mouthwash. By doing this, patients will be randomly divided into test propolis and chlorhexidine groups. After completion of randomization of the first 10 patients, this procedure will be repeated. 3 Chronic periodontits. Intervention 1: Intervention group 1: In this group, after SRP, the respective areas will be irrigated with 3cc of hydro-alcoholic solution of propolis extract 20 % (Soren Tech, Mashhad, Iran) twice a week for two weeks. Intervention 2: Intervention group 2: In this group, after SRP, 0.2 % chlorehexidine mouthwash (Shahredaru, Tehran, Iran) is prescribed for use twice a day for two weeks.
public Reyhane Eghbali Zarch
Mahan street, Zamzam street, khaniabade no, Navvab highway, Tehran.
Tehran Iran (Islamic Republic of) +98 21 5585 1131 reiihane@yahoo.com School of Dentistry, International Campus, Tehran University of Medical Sciences. scientific Mitra Askari
Mahan street, Zamzam street, khaniabade no, Navvab highway, Tehran.
Tehran Iran (Islamic Republic of) +98 21 5585 1131 askari_mitra@ymail.com School of Dentistry, International Campus, Tehran University of Medical Sciences. Iran (Islamic Republic of) Inclusion criteria: Chronic periodontitis patients; The age range of 25 to 50 years; Having deep periodontal pockets (≥5 mm) around a minimum of three teeth not adjacent to each other. Exclusion criteria: Presence of periapical changes in the respective teeth; Systemic conditions requiring antibiotic prophylaxis or affecting the progression of disease or response to treatment; History of periodontal therapy in the past six months; Use of antibiotics, Anti-inflammatory drugs, anticonvulsants, immunosuppressive drugs or calcium channel blockers in the past three months; Pregnancy; Orthodontic treatment; Smoking; Having pacemaker; Mitral valve prolapse, Use of mouthrinses during treatment. 25 years 50 years Both K05.3 chronic pericoronitis Periodontitis: NOS complex simplex Treatment - Drugs Treatment - Drugs Intervention group 1: In this group, after SRP, the respective areas will be irrigated with 3cc of hydro-alcoholic solution of propolis extract 20 % (Soren Tech, Mashhad, Iran) twice a week for two weeks. Intervention group 2: In this group, after SRP, 0.2 % chlorehexidine mouthwash (Shahredaru, Tehran, Iran) is prescribed for use twice a day for two weeks. Clinical Attachment level (CAL). Timepoint: Before intervention and one month later. Method of measurement: mm using periodontal probe. Pocket Depth (PD). Timepoint: Before intervention and one month later. Method of measurement: mm using periodontal probe. Bleeding on probing (BOP). Timepoint: Before intervention and one month later. Method of measurement: positive or negative, using periodontal probe. Gingival index (GI). Timepoint: Before intervention and one month later. Method of measurement: Average number of teeth with positive bleeding on probing, using periodontal probe. Matrix Metalloproteinase 8 level of saliva. Timepoint: Before intervention and one month later. Method of measurement: Pg/ml, ELISA TEST. Vice chancellor for research of International Campus, Tehran University of Medical Sienses. Approved 2015-11-02 Ethics committee of International Campus, Tehran University of Medical Sciences Mahan street, Zamzam street, khaniabade no, Navvab highway, Tehran. Tehran Iran (Islamic Republic of)