]>
IRCT2016103130603N1 IRCT 2017-04-14 Shahroud University of Medical Sciences The effect of probiotics on infectious disease and DNA damage in lymphocytes of dialysis patients The effect of probiotics on the serum level of endotoxin, the faecal levels of endotoxin and DNA damage in peripheral blood mononuclear lymphocytes of dialysis patients 2017-04-21 anticipated 60 Complete https://irct.ir/trial/24257 interventional Randomization: Randomized, Blinding: Not blinded, Placebo: Not used, Assignment: Parallel, Purpose: Prevention, Randomization description: Randomization assignment will be done based on sample size and permuted blocked method into four groups using computer-generated random numbers and written on closed envelopes. The participants who will sign informed consent will be divided into control or intervention groups. The allocation will be concealed from participants by closed envelopes. 3 Chronic kidney disease. Intervention 1: Intervention Group: taking probiotics capsule (4BioCap 180 mg) made by Tehran Daroo company Containing: Lactobacillus acidophilus, Bifidobacterium SPP, Streptococcus thermophilus, Lactobacillus delbrueckii bulgaricus, Dosage & Duration: 6 months, 1 capsule per day. Intervention 2: Control group: taking no intervention. Yes - There is a plan to make this available What will be shared: Serum level of endotoxin, faecal level of endotoxin and DNA damage of peripheral blood mononuclear lymphocytes When: After publishing the related article To whom: Researchers Conditions: Without any condition Where to obtain: Vice-Chancellor for Research, Shahroud University of Medical Sciences How to obtain: By sending a request email Comments:
public Alireza Jafar
Haft-e-Tir Square, Shahroud, Iran
Shahroud Iran (Islamic Republic of) 3614773947 +98 23 3239 5054 mani_jafar@yahoo.com Shahroud University of Medical Sciences scientific Mehdi Mirzaii
Haft-e-Tir Square, Shahroud, Iran
Shahroud Iran (Islamic Republic of) 3614773947 +98 23 3239 5054 mirzaii1386@gmail.com Shahroud University of Medical Sciences Iran (Islamic Republic of) over 18 years of age, glomerular filtration rate less than 15 ml/min, having routine diets 18 years no limit Both infectious diseases, pregnancy (for female participants), autoimmune or immunosuppressive diseases, taking immunosuppressive drugs or antibiotics, lactose intolerance N18 Chronic kidney disease Treatment - Drugs Treatment - Drugs Intervention Group: taking probiotics capsule (4BioCap 180 mg) made by Tehran Daroo company Containing: Lactobacillus acidophilus, Bifidobacterium SPP, Streptococcus thermophilus, Lactobacillus delbrueckii bulgaricus, Dosage & Duration: 6 months, 1 capsule per day Control group: taking no intervention Serum level of endotoxin. Timepoint: Before and after the intervention (6 months). Method of measurement: Limulus Amebocyte Lysate (LAL) kit. DNA Damage of peripheral blood mononuclear lymphocytes. Timepoint: Before and after the intervention (6 months). Method of measurement: Comet Assay. Faecel level of endotoixn. Timepoint: Before and after the intervention (6 months). Method of measurement: Limulus Amebocyte Lysate (LAL) kit. Shahroud University of Medical Sciences Approved 2016-10-08 Ethics committee of Shahroud University of Medical Sciences Haft-e-Tir Square, Shahroud, Iran Shahroud Semnan Iran (Islamic Republic of)