IRCT20161103030680N8 IRCT 2018-02-11 Shahed University Migraine in menstrual period Evaluation of acetazolamide efficacy in migraine headaches in menstrual period 2013-08-12 anticipated 100 Complete https://irct.ir/trial/24301 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Randomization description: Patients with migraine headache who attend in neurology clinic of Mostafa Khomeini hospital and are selected according to study criteria are given a number and then by use of chart of random numbers are assigned randomly in study and control groups. The group of first patient is selected by lottery, Blinding description: ِDrugs are inserted in uniform packages and code is assigned. Patients researchers and assessors are not aware of patient group. 2-3 Condition 1: Migraine headaches. Condition 2: Migraine headaches. Intervention 1: Control group:Fifty patients with migraine headaches which is aggravated during menstrual periods take Nortriptiline 0.6 milligrams / kilogram at night and Propranolol one milligrams / kilogram per day divided to two equal dose for three months. َAll patients in this group takes placebo three times daily from three days prior the usual time of menstrual period for each patient to the end of period in addition to above mentioned drugs. Intervention 2: Intervention group: Fifty patients with migraine headaches which is aggravated during menstrual periods take Nortriptiline 0.6 milligrams / kilogram at night and Propranolol one milligrams / kilogram per day divided to two equal dose for three months. ََAll patients in this group take Acetazolamide two hundred and fifty milligrams three times daily from three days before the usual time for beginning of menstrual period to the end of period in addition to above mentioned drugs. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is I am not sure about ethical problems from aspect of patients.