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IRCT2016110530709N1 IRCT 2016-12-18 Research Council of Mashhad University of Medical Sciences propranolol effect on pregnancy A comparison between misoprostol plus propranolol and misoprostol alone in labour induction ( in post term pregnancies. ) 2016-12-21 anticipated 80 Complete https://irct.ir/trial/24317 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment. 2-3 Labour induction. Intervention 1: The Intervention group recieve 20mg Propranolol tablet concurrent with sublingual Misoprostol at the begining of induction. If there is no effective contraction, the dose will be repeated after 3 hours. Intervention 2: The Control group recieve oral Placebo tablets that their shape, color and weight are similar to 20mg propranolol tablets, in the same way of the intervention group.
public Atiyeh Mohamadzade Vatanchi
Ghaem hosptal
mashhad Iran (Islamic Republic of) +98 51 3801 2477 vaatnchia@mums.ac.ir Mashhad University of Medical Sciences scientific Atiyeh Mohamadzade Vatanchi
Ghaem hospital
mashhad Iran (Islamic Republic of) +98 51 3801 2477 vatanchiha@mums.ac.ir Mashhad University of Medical Sciences Iran (Islamic Republic of) Iran (Islamic Republic of) Iran (Islamic Republic of) Inclusion criteria: nulliparous women with Gestational age more than 41 weeks ؛ Single pregnancy؛ Cephalic presentation؛ Bishop score<5؛ indication for the induction of delivery؛ admitted in academic hospitals Exclusion criteria: Pregnant women with uterus contraction؛ fetal distress؛ Suspected macrosomia؛ Polyhydroamnius؛ Systolic blood pressure less than 100mmHg؛ Pulse rate less than 60 and more than 120؛ Any history of cardiopulmonary disease ؛alcohol abuse. no limit no limit Female o61 Failed induction of labour Treatment - Drugs Placebo The Intervention group recieve 20mg Propranolol tablet concurrent with sublingual Misoprostol at the begining of induction. If there is no effective contraction, the dose will be repeated after 3 hours. The Control group recieve oral Placebo tablets that their shape, color and weight are similar to 20mg propranolol tablets, in the same way of the intervention group. The time of begining of effective contractions. Timepoint: Before Intervention and after effective contractions. Method of measurement: minute. The time lapse from the beginning of induction to 4cm dilatation. Timepoint: before intervention and at the time of 4cm dilatation. Method of measurement: minute. The time lapse from the beginning of induction to delivery. Timepoint: before intervention and at the time of delivery. Method of measurement: minute. Neonatal Apgar score. Timepoint: At the first and the fifth minutes after birth. Method of measurement: Apgar scale. Neonatal NICU admission. Timepoint: The first day after the birth. Method of measurement: Questionnaire. Cesarean rate. Timepoint: Birth time. Method of measurement: Questionnaire. Research Council of Mashhad University of Medical Sciences Approved 2016-08-17 Mashhad University of Medical Sciences Building Qureshi, Daneshgah street, Taghi Abad Mashhad Iran (Islamic Republic of)