IRCT2017032530808N3 IRCT 2017-04-24 Vice chancellor for research, Jahrom University of Medical Sciences The effects of Laser and Microneedling combined with phototherapy for treating vitiligo in resistant of hair skin Assay of the CO2 fractional laser and micro needling plus hair follicle transplantation in the treatment of refractory and stable vitiligo. 2016-01-13 anticipated 20 Complete https://irct.ir/trial/24364 interventional Randomization: N/A, Blinding: Not blinded, Placebo: Not used, Assignment: Single, Purpose: Treatment. N/A Vitiligo. Comparable vitiliginous lesions were selected from both sides of the body. On Day 0, heavily pigmented follicular grafts were harvested from the scalp by follicular unit extraction and transplanted in a 1-cm grid pattern throughout the selected lesions. At Day 30±4 and Day 60±4, left-sided lesions received single treatments with fractional CO2 laser, MX-7000 (10,600 nm, 100 MJ pulse energy and 200 spots/cm3 in static mode) (Daeshin Enterprise Corporation, Seoul, Korea). Right-sided lesions received 1.5-2 mm needle length-assisted microneedling until pinpoint bleeding was achieved. On Day 30±4 and Day 60±4, silver sulfadiazine ointment was applied to treated skin, twice daily, for 5 days without occlusion.On Day 41±2, right and left-sided lesional skin received NBUVB phototherapy (dermalight 1,000/1,000 L, 800 W, Power supply: 230 V/50 Hz; Dr. Honle medizinitechnik, GmbH, Germany) three times a week until Day 60±4; phototherapy was restarted on day 71±2. The phototherapeutic dose was increased by 15% at each treatment interval and was completed by Day 100±4 (for a total of 12 weeks of treatment). Clobetasol 45% solution was applied twice daily throughout the phototherapy phase of the study.The diameter of repigmentation around each graft was measured with appropriately calibrated calipers at baseline, Day 30±4, Day 60±4 and Day 100±4..