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IRCT2017021430855N1 IRCT 2017-02-14 Tehran University of Medical Sciences, The Vice-Chancellery for Research The Effect of Intravenous Propofol on Local Anesthesia Studying the effect of intravenous Propofol used with two different volumes of local anesthetic(Bupivacaine) on sensory and motor blockade in patients undergoing upper limb surgery by sonographic supraclavicular brachial plexus block approach 2017-01-20 anticipated 90 Complete https://irct.ir/trial/24398 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment. N/A Supraclavicular Blochade of the Brachial Plexus. Intervention 1: Supraclavicular injection of 30ml Bupivacaine 0.5% + Administration of 25mcg/kg/min IV Propofol. Intervention 2: Supraclavicular injection of 20ml Bupivacaine 0.5% + Administration of 25mcg/kg/min IV Propofol. Intervention 3: Supraclavicular injection of 30ml Bupivacaine 0.5% + Administration of 25mcg/kg/min IV normal saline as placebo.
public Mehrdad Sadri
Dormitory of Tehran University of Medical Sciences, 16th St, Kargar Shomali St
Tehran Iran (Islamic Republic of) 008337249292 m.sadri71@gmail.com Tehran University of Medical Sciences, School of Medicine scientific Dr. Reza Atef Yekta
Shariati Hospital, Jalal Al Ahmad crossroad, Kargar Shomali St, Tehran
Tehran Iran (Islamic Republic of) +218 4901 rezaatefyekta@yshoo.com Shariati Hospital Iran (Islamic Republic of) Inclusion Criteria: Ages between 20 and 50; ASA classes: I,II,III; BMI under 35; Absence of the history of drug induced hypersensitivity; Taking of informed consent Exclusion Criteria: Failure of supraclavicular blockade; Need to General Anesthesia 20 years 50 years Both Treatment - Drugs Treatment - Drugs Treatment - Drugs Supraclavicular injection of 30ml Bupivacaine 0.5% + Administration of 25mcg/kg/min IV Propofol Supraclavicular injection of 20ml Bupivacaine 0.5% + Administration of 25mcg/kg/min IV Propofol Supraclavicular injection of 30ml Bupivacaine 0.5% + Administration of 25mcg/kg/min IV normal saline as placebo Duration of Motor Blockage. Timepoint: During and after the intervention. Method of measurement: Physical examination by the physician. Duration of Sensory Blockage. Timepoint: During and after the intervention. Method of measurement: Physical examination by the physician. Onset of the Motor Blockage. Timepoint: During the intervention. Method of measurement: Physical examination by the physician. Onset of the Sensory Blockage. Timepoint: During the intervention. Method of measurement: Physical examination by the physician. Patient's feeling of pain. Timepoint: After the intervention in the same admission. Method of measurement: Visual Analogue Scale (VAS). The measure of motor blockade. Timepoint: During and after the intervention. Method of measurement: Lovett Rating Scale. The time of the first opioid request by the patient. Timepoint: After the intervention in the same admission. Method of measurement: By using PCA(Patient Controlled Anaesthesia). Administered opioid dosage in 24 hours. Timepoint: After the intervention in the same admission. Method of measurement: Patient Medical Document. Duration of the surgery. Timepoint: During the intervention. Method of measurement: Patient Medical Document. Nausea and vomiting after the surgery. Timepoint: After the intervention in the same admission. Method of measurement: Asking the patient. Mean arterial blood pressure 1 minute after the blockade. Timepoint: 1 minute after the blockade. Method of measurement: Non-invasive automatic manometer. Mean arterial blood pressure 3 minutes after the blockade. Timepoint: 3 minutes after the blockade. Method of measurement: Non-invasive automatic manometer. Mean arterial blood pressure 5 minutes after the blockade. Timepoint: 5 minutes after the blockade. Method of measurement: Non-invasive automatic manometer. Mean arterial blood pressure 1 minute after the recovery. Timepoint: 1 minute after recovery admission. Method of measurement: Non-invasive automatic manometer. Mean arterial blood pressure 3 minutes after the recovery. Timepoint: 3 minutes after the recovery admission. Method of measurement: Non-invasive automatic manometer. Mean arterial blood pressure 5 minutes after the recovery. Timepoint: 5 minutes after the recovery admission. Method of measurement: Non-invasive automatic manometer. Heart rate 1 minute after the blockade. Timepoint: 1 minute after the blockade. Method of measurement: Pulse Oxymetery. Heart rate 3 minutes after the blockade. Timepoint: 3 minutes after the blockade. Method of measurement: Pulse Oxymetery. Heart rate 5 minutes after the blockade. Timepoint: 5 minutes after the blockade. Method of measurement: Pulse Oxymetery. Heart rate 1 minute after the recovery. Timepoint: 1 minute after the recovery admission. Method of measurement: Pulse Oxymetery. Heart rate 3 minutes after the recovery. Timepoint: 3 minutes after the recovery admission. Method of measurement: Pulse Oxymetery. Heart rate 5 minutes after the recovery. Timepoint: 5 minutes after the recovery admission. Method of measurement: Pulse Oxymetery. Tehran University of Medical Sciences, The Vice-Chancellery for Research Approved 2016-11-22 Research Ethics Committee of Tehran University of Medical Sciences, School of Medicine Plate 23, 16th of Azar St, Keshavarz Blvd Tehran Iran (Islamic Republic of)