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IRCT201409042639N14 IRCT 2014-10-10 Research Deputy of Shahid Sadoughi University of Medical Sciences , Yazd, Iran Effect of the order of injecting 18th month of age vaccines on pain Clinical trial of evaluation of 18th month of age vaccines injection order (intramuscular first and then subcutaneous or subcutaneous first and then intramuscular) on pain of intramuscular injection of diphtheria, pertussis and tetanus vaccine 2014-08-26 anticipated 60 Complete https://irct.ir/trial/2446 interventional Randomization: Randomized, Blinding: Not blinded, Placebo: Not used, Assignment: Parallel, Purpose: Other, Other design features: The children in this trial will be randomized by random numbers table. 1 vaccination. Intervention 1: intramuscular injection of a single dose of DPT (diphtheria, pertussis and tetanus) vaccine and then subcutaneous injection of a single dose of combination of measles, mumps and rubella vaccines. Intervention 2: subcutaneous injection of a single dose of combination of measles, mumps and rubella vaccines and then intramuscular injection of a single dose of DPT (diphtheria, pertussis and tetanus) vaccine.
public Dr. Hosein Gholami
Shahid Sadoughi Hospital , Ave - Sina Blvd, Shahid Ghandi Blvd, Yazd, I.R.Iran
Yazd Iran (Islamic Republic of) +98 35 1822 4000 hgholami26@yahoo.com Shahid Sadoughi University of Medical Sciences , Yazd , Iran scientific Dr.Razieh Fallah
Shahid Sadoughi Hospital , Ave - Sina Blvd, Shahid Ghandi Blvd, Yazd, I.R.Iran
Yazd Iran (Islamic Republic of) +98 35 1822 4000 FALLAH@ssu.ac.ir Shahid Sadoughi University of Medical Sciences , Yazd , Iran Iran (Islamic Republic of) Inclusion criteria: 18 months of age, being in a healthy medical condition and referring for vaccination to primary health care center Exclusion criteria: neurodevelopmental delay, severe congenital malformation and receiving sedative hypnotic drugs within the past 24 hours 1 year 1 year Both Z27 Need for immunization against combinations of infectious diseases Prevention Prevention intramuscular injection of a single dose of DPT (diphtheria, pertussis and tetanus) vaccine and then subcutaneous injection of a single dose of combination of measles, mumps and rubella vaccines subcutaneous injection of a single dose of combination of measles, mumps and rubella vaccines and then intramuscular injection of a single dose of DPT (diphtheria, pertussis and tetanus) vaccine Pain score during diphtheria, pertussis and tetanus (DPT) vaccine injection. Timepoint: time of needle insertion to skin. Method of measurement: Modified Behavioral Pain Scale table. Pain score during measles, mumps and rubella (MMR) vaccine injection. Timepoint: time of measles, mumps and rubella (MMR) vaccine injection. Method of measurement: Modified Behavioral Pain Scale table. Obtaining of pain score of less than four during diphtheria, pertussis and tetanus (DPT) vaccine injection. Timepoint: time of diphtheria, pertussis and tetanus (DPT) vaccine injection. Method of measurement: Modified Behavioral Pain Scale table. Duration of baby crying after injection of DPT vaccine. Timepoint: every 10 seconds after vaccine injection until stopping of crying. Method of measurement: by chronometer. Research Deputy of Shahid Sadoughi University of Medical Sciences , Yazd, Iran Approved 2014-08-24 Ethics committee of Shahid Sadoughi University of Medical Sciences, Yazd, Iran central building of university, Bahonar square Yazd Iran (Islamic Republic of)