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IRCT2016112331046N1 IRCT 2017-05-29 Vice-Chancellor for Research of Qazvin University of Medical Sciences The effect of progesterone in the prevention of preterm delivery Tocolysis vaginal progesterone ether as preservatives in preventing preterm delivery 2015-03-21 anticipated 200 Complete https://irct.ir/trial/24500 interventional Randomization: Randomized, Blinding: Not blinded, Placebo: Not used, Assignment: Parallel, Purpose: Prevention. 2-3 Preterm labour without delivery. Intervention 1: Giving 200mg vaginal progesteronin in case group after confirmed preterm laber and treat with sulfat manuazum and corticosteroid.If the pain isnt offafterr 12 hour it is repeated then after of control pain it is giving daily until 34 weeks or delivery. Intervention 2: In control group after confirmed preterm laber none drug inadditon of sulfat manuaziom and corticosteroid is given.
public Dr Fahimeh Takallo
Kowsar Hospital, Taleghani St, Qazvin, Iran
Qazvin Iran (Islamic Republic of) +98 28 3223 6374 fahimeh_takallo@yahoo.com Kowsar Hospital scientific Dr Fateme Lalooha
Kowsar Hospital, Taleghani St, Qazvin, Iran
Qazvin Iran (Islamic Republic of) +98 28 3223 6374 lalooha44@yahoo.com Kowsar Hospital Iran (Islamic Republic of) Inclusion criteria: singleton pregnancies between 24-34 weeks gestational age; premature delivery confirmation by: regular uterine contractions (with a length of more the 30 second and more than 3 times per 10 minutes) with dilatation of the cervix 0-2 centimetres in nolipars and 0-3 centimetre in moltipars; intact fetal membranes. exclusion criteria: rupture of the membranes during treatment; fetal anomaly; any evidence of fetal distress (chorioamnionitis, Preeclampsia, placental abruption, intrauterine growth restriction); sensitivity to progesterone (dizziness, headache, depression, high blood sugar during usage); history of medical illness in the mother (high blood pressure, cancer, epilepsy, chronic thromboambolic disease, liver disease); patients with asthma treated with oral beta-adrenergic. no limit no limit Female O60.0 Preterm labour without delivery Treatment - Drugs Treatment - Drugs Giving 200mg vaginal progesteronin in case group after confirmed preterm laber and treat with sulfat manuazum and corticosteroid.If the pain isnt offafterr 12 hour it is repeated then after of control pain it is giving daily until 34 weeks or delivery. In control group after confirmed preterm laber none drug inadditon of sulfat manuaziom and corticosteroid is given. Delay of delivery. Timepoint: post partum. Method of measurement: documented data. Neonatal distress. Timepoint: after delivery. Method of measurement: Documented data. Birth weight. Timepoint: After delivery. Method of measurement: Documented data. Apgar at birth. Timepoint: After delivery in 1 and 5 minutes. Method of measurement: Documented data. Gestational age at birth. Timepoint: after delivery. Method of measurement: documented data. Perinatal Mortality. Timepoint: after delivery. Method of measurement: documented data. Fetal death. Timepoint: after delivery. Method of measurement: documented data. NICU admission. Timepoint: after delivery. Method of measurement: documented data. NO NO Vice-Chancellor for Research of Qazvin University of Medical Sciences Approved 2015-11-04 Ethics committee of Qazvin University of Medical Sciences Bahonar Blvd, Qazvin Qazvin Iran (Islamic Republic of)