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IRCT2016112431074N1 IRCT 2017-02-13 Zanjan University of Medical Sciences Therapeutic effect of skin allograft in deep second degree burn wounds Comparison of therapeutic effect of dressing with skin allograft and silver sulfadiazine in deep second degree burn wounds in Zanjan Ayatollah Mousavi hospital, 2016-2017 2016-03-20 anticipated 50 Complete https://irct.ir/trial/24517 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Health service research. N/A Deep second degree burn wounds of limbs and trunk. Intervention 1: In control group we used silver sulfadiazine ointment daily after washing the wounds.we consume 20 gram of ointment for each percent of burn wound(each tube is consist of 50 gram of ointment). Intervention 2: In intervention group we applied skin allografts produced by ITP company(Iranian tissue products) as a biological bandage.first we sutured the allograft with few simple stiches then with we badage with wet gauze (under anestesia in OR)the day after procidure we remove the bandage and dry it by heat lamp and do not bandage any more.
public Ali Farahanchi Baradaran
Ayatollah Mousavi hospital, Gavazang road
Zanjan Iran (Islamic Republic of) +98 24 3313 0000 dr-ali-farahanchi@zums.ac.ir Zanjan University of Medical Sciences scientific Dr. Mohammad Hosein Moghimi
Ayatollah Mousavi hospital, Gavazang road
Zanjan Iran (Islamic Republic of) +98 24 3313 0000 m13757@zums.ac.ir Department of Surgery, Zanjan University of Medical Sciences Iran (Islamic Republic of) Inclusion criteria: patients with thermal deep second degree burn wound who are admitted in our ward, age above 18,with out respiratory burning, with out any comorbidities like addiction. History of DM, renal disease, malignancies, psychiatric problems and non- pregnant patients. Exclusion criteria: head and neck burn wounds; genitalia burn wounds; pregnant patients; third and forth degree burn wounds; unstable patients; patients with burn wounds BSA>20% or BSA<10%; psychiatric patients; addict and smoker patients; patients with other comorbidities like renal and hepatic problem, DM, malnutrition and immunocompromised patients, respiratory burning, old wounds; infected wounds and age below 18. 18 years 65 years Both T21.2 Burn of second degree of trunk Treatment - Drugs Treatment - Other In control group we used silver sulfadiazine ointment daily after washing the wounds.we consume 20 gram of ointment for each percent of burn wound(each tube is consist of 50 gram of ointment). In intervention group we applied skin allografts produced by ITP company(Iranian tissue products) as a biological bandage.first we sutured the allograft with few simple stiches then with we badage with wet gauze (under anestesia in OR)the day after procidure we remove the bandage and dry it by heat lamp and do not bandage any more. Pain. Timepoint: Daily during admission. Method of measurement: VAS scale. Epitelialisation duration. Timepoint: days: 7, 14 and 30. Method of measurement: Physical examination. Amount of IV pain killer. Timepoint: Daily during admission. Method of measurement: Nursing report. Finall remaining scar. Timepoint: Day 30 after intervention. Method of measurement: Physical examination and questionare. Addmision days. Timepoint: Time of discharge. Method of measurement: Discharge ward. Number of bandage refreshment. Timepoint: Daily during admission. Method of measurement: Nursing report and direct checking. Treatment cost. Timepoint: At the time of discharge. Method of measurement: Finall bill. Infection. Timepoint: During admission. Method of measurement: Culture from wound. Zanjan University of Medical Sciences Approved 2016-11-23 Zanjan University of Medical Sciences Zanjan University of Medical Sciences, Azadi blvd. Zanjan Iran (Islamic Republic of)