IRCT20161126031091N2 IRCT 2018-09-11 Tehran University of Medical Sciences Effect of mannitol and hypertonic saline on brain tumor Evaluation of effect of preoperative infusion of mannitol vs hypertonic saline on ICP and inflammatory biomarkers in brain tumor patients undergo craniotomy at Sina hospital,a randomized clinical trial 2017-09-23 anticipated 60 Complete https://irct.ir/trial/24524 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: Our randomization method was block balance method. we used randomized number table to apply method, Blinding description: The patient who undergoes craniotomy will be unconscious while we infuse the fluid, so this side will be considered blind. the neurosurgeon will not know which osmotic solution we would use before start of the surgery. so this RCT will be double blind. N/A brain tumor. Intervention 1: patients in intervention group received 2-3 meq/kg hypertonic saline 5%. they were taken a blood sample (about 3 cc) before being administered hypertonic saline and 72 hours after the operation. all samples were stored in a freezer until measuring by S100B laboratory kit. Intervention 2: Control group: patients received 1 g / kg Mannitol 20%.they were taken a blood sample (about 3 cc) before being administered Mannitol and 72 hours after the operation. all samples were stored in a freezer until measuring by S100B laboratory kit. No - There is not a plan to make this available Justification or reason for not sharing IPD is there is no more information,