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IRCT2016112631107N1 IRCT 2017-05-24 Tehran University Of Medical Sciences Vice Chancellor Of Research evaluating the effect of an anesthetic agent on the duration of anesthesia and analgesia among chronic opium abusers studying the effects of adding dexmedetomidine to bupivacaine on supraclavicular nerve block in upper limb orthopedic surgery among chronic opium abusers compared with non users. 2017-06-22 anticipated 84 Complete https://irct.ir/trial/24536 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment. N/A Regional anesthesia. Intervention 1: second intervention group receives 30 ml hyperbaric bupivacaine along with 20 micro gram dexmedetomidine to perform regional anesthesia. Intervention 2: first intervention group receives 30 ml hyperbaric bupivacaine along with 2 ml saline as placebo to perform regional anesthesia. Intervention 3: second control group receives 30 ml hyperbaric bupivacaine along with 20 micro gram dexmedetomidine to perform regional anesthesia. Intervention 4: first control group receives 30 ml hyperbaric bupivacaine along with 2 ml saline as placebo to perform regional anesthesia.
public Dr Maryam Taheri
Shariati Hospital, Jalal-e-Al-e-Ahmad High Way, District 6, Tehran, Iran
Tehran Iran (Islamic Republic of) 1411713135 +98 21 84901 Aug.taheri@gmail.com Shariati Hospital, Anesthesilogy Department scientific Dr Reza Atef Yekta
Anesthesiology Unit, Surgery Room, Shariati Hospital, Jalal-Ae-Al-e-Ahmad High Way,District 6, Tehran, Iran
Tehran Iran (Islamic Republic of) 1411713135 +98 21 84901 rezaatefyekta@yahoo.com Shariati Hospital, Anesthesiology Department Iran (Islamic Republic of) inclusion criteria: (ASA) physical status class I and II; male; current smokers; aged between 18-60; scheduled for elective upper limb orthopedic surgery under supraclavicular nerve block. exclusion criteria: Patients with any contraindications to supraclavicular nerve block; patients with addiction to any substance other than opium and cigarettes; patients with known history of cardiac, respiratory, or psychological diseases; block failure of any nerve distributions (i.e. if the patient feel pain in those regions), the patient will be excluded from the study, even when the block is adequate to perform the operation. 18 years 60 years Male T41.3, Y48 Local anaesthetics Treatment - Drugs Treatment - Drugs Treatment - Drugs Treatment - Drugs second intervention group receives 30 ml hyperbaric bupivacaine along with 20 micro gram dexmedetomidine to perform regional anesthesia first intervention group receives 30 ml hyperbaric bupivacaine along with 2 ml saline as placebo to perform regional anesthesia second control group receives 30 ml hyperbaric bupivacaine along with 20 micro gram dexmedetomidine to perform regional anesthesia first control group receives 30 ml hyperbaric bupivacaine along with 2 ml saline as placebo to perform regional anesthesia Sensory block onset. Timepoint: sensory block will be checked continuously after completion of injection until complete sensory and motor block. Method of measurement: pinprick test and a verbal rating scale from 100% (normal sensation) to 0 (no sensation). Sensory block duration. Timepoint: after complete sensory block and every 15 minutes following the end of operation. Method of measurement: pinprick test and a verbal rating scale from 100% (normal sensation) to 0 (no sensation). Motor block onset. Timepoint: motor block will be checked continuously after completion of injection until complete motor block. Method of measurement: Lovett rating scale. Motor block duration. Timepoint: after complete motor block and every 15 minutes following the end of operation. Method of measurement: the Lovett rating scale. Systolic blood pressure. Timepoint: continuously monitoring while the surgery is performing. Method of measurement: manometer. Diastolic blood pressure. Timepoint: continuously monitoring while the surgery is performing. Method of measurement: manometer. Heart rate. Timepoint: continuously monitoring while the surgery is performing. Method of measurement: Monitoring. Respiratory depression. Timepoint: continuously monitoring while the surgery is performing. Method of measurement: O2 saturation & Respiratory Rate. Drug consumption in the 24 hours after surgery. Timepoint: patient need. Method of measurement: Medical records. Tehran University Of Medical Sciences Vice Chancellor Of Research Approved 2016-10-05 Research Ethics Committee of the Medical Faculty of Tehran University of Medical Sciences Professional Doctoral Theses Unite, Ground Floor, Education Building, Faculty of Tehran University of Medical Sciences Tehran Iran (Islamic Republic of)