IRCT2016121431406N1 IRCT 2017-01-16 Shiraz University of Medical Sciences The therapeutic effects of a topical preparation from Wallflower and Damask Rose on anal fissure. Comparison the therapeutic effect of traditional preparation compounded from Wallflower and Damask Rose flowers with the therapeutic effect of anti-fissure cream on anal fissure healings in patients having age of 20-50 years. 2017-02-19 anticipated 90 Complete https://irct.ir/trial/24713 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment. N/A Acute anal fissure. Intervention 1: Patients with acute anal fissure in positive control group with conventional medication. which is administered as a rectal ointment for two weeks, twice a day, each time a tip of the finger (0.5 g). Intervention 2: Patients with acute anal fissure in traditional drug group (cerate supplies of rose oil and wallflower oil and beeswax) which is administered as a rectal ointment for two weeks, twice a day, each time a tip of the finger (0.5 g). Intervention 3: Patients with acute anal fissure in placebo group: a simple cerate base (cerate of sesame oil and wax) which is administered as a rectal ointment for two weeks, twice a day, each time a tip of the finger (0.5 g).