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IRCT2017012031423N1 IRCT 2017-05-22 Vice Chancellor for research of Mashhad University of Medical Sciences The influence of Curcumin on Non-alcoholic fatty liver disease Evaluation of influence of Curcumin on non-invasive liver marker`s in patients with nonalcoholic fatty liver disease 2017-02-19 anticipated 60 Complete https://irct.ir/trial/24720 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Other design features: Sealed envelopes. 2-3 Nonalcoholic fatty liver disease. Intervention 1: Control group: Patients in groups of 30 for a period of two months Placebo 2 times a day will be prescribed. Intervention 2: Intervention group: Patients in groups of 30 for a period of two months curcumin(Sinacurcumin; nanomicelles) to 80 mg 2 times a day will be prescribed.
public DR Beheshti Namdar, Ali
Ghaem hospital; Ahmad abad
Mashhad Iran (Islamic Republic of) +98 51 3843 4637 beheshtia@mums.ac.ir Mashhad University of Medical Sciences scientific DR Beheshti Namdar, Ali
Ghaem Hospital; Ahmad abad
Mashhad Iran (Islamic Republic of) +98 51 3843 4637 beheshtia@mums.ac.ir Mashhad Universty of medical Sciences Iran (Islamic Republic of) Inclusion criteria: 1. having ALT and AST upper than highest normal level 2. have at least one of the following: A) Diabetes B) Hyperlipidemia C) Obesity 3. The age of 15 to 60 Exclusion criteria: 1. Alcohol consumption 2. Get a positive serology of viral hepatitis 3. ANA or AMA positive test, Alpha1 Antitrypsin, Low serum levels of Seroloplasin or high levels of antibodies of ASMA or LKM. 4. High ferritin 450 or Iron/TIBC> 45% 5. The patient before the intervention or during the intervention, affected with acute or chronic disease that causes in LFT disorders. 6.The patient before the intervention or during the intervention is consuming medicine that potentially capable of Disrupting the LFT. 7. Pregnancy 8. Patients Younger than 15 or older than 60. 15 years 60 years Both K76.0 Fatty (change of) liver, not elsewhere classified Placebo Treatment - Drugs Control group: Patients in groups of 30 for a period of two months Placebo 2 times a day will be prescribed Intervention group: Patients in groups of 30 for a period of two months curcumin(Sinacurcumin; nanomicelles) to 80 mg 2 times a day will be prescribed BMI. Timepoint: Before and two months after intervention. Method of measurement: Measuring the weight by Scale and height by Metre. ALT. Timepoint: Before and two months after intervention. Method of measurement: Serology. AST. Timepoint: Before and two months after intervention. Method of measurement: Serology. ALP. Timepoint: Before and two months after intervention. Method of measurement: Serology. TG. Timepoint: Before and two months after intervention. Method of measurement: Serology. Total Cholestrol. Timepoint: Before and two months after intervention. Method of measurement: Serology. HDL. Timepoint: Before and two months after intervention. Method of measurement: Serology. FBS. Timepoint: Before and two months after intervention. Method of measurement: Serology. Serum Insulin. Timepoint: Before and two months after intervention. Method of measurement: Serology. LDL. Timepoint: Before and two months after intervention. Method of measurement: Serology. Total Bilirubin. Timepoint: Before and two months after intervention. Method of measurement: Serology. Direct Bilirubin. Timepoint: Before and two months after intervention. Method of measurement: Serology. Vice Chancellor for research of Mashhad University of Medical Sciences Approved 2016-12-13 Ethics committee of mashhad university of medical sciences University street, Ghoreishi building, Vice Chancellor of Research Mashhad University of Medical Sciences Mashhad Iran (Islamic Republic of)