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IRCT2017011932026N2 IRCT 2017-04-27 Vice Chancellor for research of School of Public Health, Shahid Sadoughi University of Medical Scien The effect of L carnitine in women with knee osteoarthritis The effect of L carnitine on clinical symptoms, lipid profile and oxidative stress in obese women with knee osteo arthiritis under weight loss diet 2017-01-29 anticipated 76 Complete https://irct.ir/trial/25050 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Supportive, Other design features: in this study will be randomly assigned to 2 groups by using the table of random numbers. 2 knee osteo arthritis. Intervention 1: control group:this group will consume of one tablet(1000mg placebo) one time a day after meals (lunch or breakfast) with weight loss diet for 12 weeks. tablets will produce from Karen Company in Yazd. Intervention 2: intervention group:this group will consume of one tablet(1000mg L carnitine) one time a day after meals (lunch or breakfast) with weight loss diet for 12 weeks. tablets will produce from Karen Company in Yazd.
public Farnaz Baghban
Shohaday-e-Gomnam Blvd., Alem Sq., Yazd, Iran
Yazd Iran (Islamic Republic of) 8915173160 +98 71 3730 5474 farnaz_baghban@yahoo.com School of Public Health, Shahid Sadoughi University of Medical Sciences, scientific Dr Mahdie Hoseinzadeh
Shohaday-e-Gomnam Blvd., Alem Sq., Yazd, Iran
Yazd Iran (Islamic Republic of) 8915173160 +98 35 3149 2232 hoseinzade.mahdie@gmail.com School of Public Health, Shahid Sadoughi University of Medical Sciences Iran (Islamic Republic of) Inclusion criteria: women؛ age between 45 to 70؛ Early detection of osteoarthritis؛ body mass index more than25؛ Lack of weight loss diets over the past three months؛ lack of participate in the intervention program the past three months Exclusion: heart disease؛ hypothyroidism؛ rheumatoid arthritis؛ hepatic disease؛kidney disease and knee sergury 45 years 70 years Female M15.0 Primary generalized (osteo)arthrosis Treatment - Drugs Treatment - Drugs control group:this group will consume of one tablet(1000mg placebo) one time a day after meals (lunch or breakfast) with weight loss diet for 12 weeks. tablets will produce from Karen Company in Yazd. intervention group:this group will consume of one tablet(1000mg L carnitine) one time a day after meals (lunch or breakfast) with weight loss diet for 12 weeks. tablets will produce from Karen Company in Yazd. Pain. Timepoint: before intervention and 12 weeks after the intervention. Method of measurement: womac questionnaire. Lipid profile(HDL, LDL, TG, Cho). Timepoint: before intervention and 12 weeks after the intervention. Method of measurement: with special kits. CRP. Timepoint: before intervention and 12 weeks after the intervention. Method of measurement: with special kits. Malondialdehyde. Timepoint: before intervention and 12 weeks after the intervention. Method of measurement: with special kits. Waist, Hip circumference. Timepoint: before intervention and 12 weeks after the intervention. Method of measurement: meter. Weight, fat mass, free fat mass. Timepoint: before intervention and 12 weeks after the intervention. Method of measurement: Omron digital Scale(BF11). Vice Chancellor for research of School of Public Health, Shahid Sadoughi University of Medical Scien Approved 2010-09-23 Ethics committee of School of Public Health, Shahid Sadoughi University of Medical Sciences, Shohaday-e-Gomnam Blvd., Alem Sq., Yazd, Iran Yazd Iran (Islamic Republic of)