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IRCT201102232709N17 IRCT 2011-03-11 Vice-chancellor for Research, Tehran University of Medical Sciences Comparing the effects of pomegranate and orange juice in non-alcoholic fatty liver disease patients Comparing the effects of pomegranate and orange juice on serum total antioxidant capacity, MDA, TNF-α, ALT and AST enzymes, lipoproteins, insulin resistance and metabolic syndrome indices in non- alcoholic fatty liver patients 2011-04-04 anticipated 70 Complete https://irct.ir/trial/2530 interventional Randomization: Randomized, Blinding: Not blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment. N/A non-alcoholic fatty liver disease. Intervention 1: 250 ml/day pomegranate juice for 12 weeks. Intervention 2: 250ml/day orange juice for 12 weeks.
public Dr Farzad Shidfar
Number 60, Alvand street, Argentina square, Tehran
Tehran Iran (Islamic Republic of) 1516846515 +98 21 8877 9118 farzadshidfar@yahoo.com Faculty of Public Health of Tehran University of Medical Sciences scientific Dr Farzad Shidfar
Number 60, Alvand street, Argentina square, Tehran
Tehran Iran (Islamic Republic of) 1516846515 +98 21 8877 9118 farzadshidfar@yahoo.com Faculty of Public Health of Tehran University of Medical Sciences Iran (Islamic Republic of) Iran (Islamic Republic of) Inclusion Criteria: signing written informed consent, age between 30 and 65, diagnosis of non-alcoholic fatty liver disease by fatty infiltration on ultrasound and abnormal serum liver function tests (AST or ALT>30 u/l in men and >20 in women), no smoking, BMI≥ 25, no pregnancy or lactation, no use of dietary supplements one month prior to enrollment, not having diabetes, renal impairment, acute heart disease, thyroid disease, other form of liver disease (viral or autoimmune hepatitis, metabolic and hereditary liver disease) and any diseases that can affect on body weight, not having severe gaining or losing weight diet in the 3 month prior to the enrollment, no use of medication that could affect body weight in the 3 month prior to the enrollment, no use of drugs that induces steatosis (amidarone, methotrexate, systemic glucocorticoid, tetracycline, tamoxifen, estrogen, anabolic steroids, valporic acid) Exclusion Criteria: those who are not interested in participating in the study, pharmacological treatment with some potential treatment, any diseases which need special treatment, pregnancy during the study period 30 years 65 years Both K76.0 Other Other 250 ml/day pomegranate juice for 12 weeks 250ml/day orange juice for 12 weeks AST enzyme. Timepoint: before & after intervention (after 12 weeks intervention. Method of measurement: enzymatic colorimetry kit. ALT enzyme. Timepoint: before & after intervention (after 12 weeks intervention. Method of measurement: enzymatic colorimetry kit. Hepatic fat infiltration status. Timepoint: before & after intervention (after 12 weeks intervention. Method of measurement: ultrasound. MDA. Timepoint: before & after intervention (after 12 weeks intervention. Method of measurement: colorimetry kit. TNF-α. Timepoint: before & after intervention (after 12 weeks intervention. Method of measurement: ELISA. Total antioxidant capacity. Timepoint: before & after intervention (after 12 weeks intervention. Method of measurement: colorimetry kit. Fasting Insulin Level. Timepoint: before & after intervention (after 12 weeks intervention). Method of measurement: ELISA. Fastinf blood sugar. Timepoint: before & after intervention (after 12 weeks intervention). Method of measurement: enzymatic colorimetry kit. HOMA-R. Timepoint: before & after intervention (after 12 weeks intervention). Method of measurement: Calculating. LDL-C. Timepoint: before & after intervention (after 12 weeks intervention). Method of measurement: immunoturbidimetry. HDL-C. Timepoint: before & after intervention (after 12 weeks intervention). Method of measurement: immunoturbidimetry. Triglyceride. Timepoint: before & after intervention (after 12 weeks intervention). Method of measurement: colorimetry. Total colestrol. Timepoint: before & after intervention (after 12 weeks intervention). Method of measurement: colorimetry. Blood pressure. Timepoint: before & after intervention (after 12 weeks intervention). Method of measurement: sphygmomanometer. Gastrointestinal & Liver Disease Research Center (Firoozgar GILDRC) Vice-chancellor for Research, Tehran University of Medical Sciences Gastrointestinal & Liver Disease Research Center (Firoozgar GILDRC) Approved 2010-10-10 Faculty of Public Health of Tehran University of Medical Sciences Number 60, Alvand street, Argentina square, Tehran Tehran Iran (Islamic Republic of)