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IRCT20170220032672N2 IRCT 2018-04-23 Shahed University Effect of thymus essential oil in prevention of ventilator associated pneumonia Comparison of effectiveness of inhaled thymus essential oil with placebo in preventing Ventilator Associated Pneumonia (VAP) 2017-10-23 anticipated 106 Complete https://irct.ir/trial/25391 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Prevention, Randomization description: Block randomization, individual randomization unit, randomized random-numbered randomization table, drop-offs by pharmacologist, randomly assigned drug or drug-free material from the researcher's eye according to the table. The researcher randomly employs a dropper from the oven bag each time. Dropper with codes 1 to 106; in the middle of the patient's death, the droplet code is declared to the pharmacologist and the same code is replaced with the contents in the bag, Blinding description: The use of a dark dropper, the color of the drug, is not known; although the drug and the agent are mixed with a color on the basis of sesame oil and with amolsifiers. The drug is labeled by a scientist other than the researcher, and the researcher does not know the contents of the contents. The caregiver also No information is available on the contents of the dropper. 3 Ventilator associated pneumonia. Intervention 1: Intervention group:15 drops or 1 cc thymus oil essential 1/2% on the basis of sesame oil with 9 cc distilled water every 12 hours for 10 days nebulizer. Intervention 2: Control group: 15 drops or 1 cc placebo (containing distilled water in the base of the oil Sesame) with 9 cc distilled water every 12 hours for 10 days nebulizer. No - There is not a plan to make this available Justification or reason for not sharing IPD is Data are confidential.
public Somayeh Valipour Dehkordi
Parastar Street
Shahrekord Iran (Islamic Republic of) 8815713471 +98 38 3222 0016 valipoor.somaye@yahoo.com Hajar hospital scientific Mohammad Reza Heidari
Shahed University, Opposite Holy Shrine of Imam Khomeini, Khalij Fars Expressway, Tehran, Iran
Tehran Iran (Islamic Republic of) 3319118651 +98 21 51210 mheidari@shahed.ac.ir Shahed University Iran (Islamic Republic of) Aged 18 years and above Under invasive mechanical ventilation 18 years no limit Both Clinical Pulmonary Infection Score (CPIS) more than 6 history of allergy sepsis acute phase Cancer trauma to the jaw, face and chest J17.8 Pneumonia in other diseases classified elsewhere Prevention Prevention Intervention group:15 drops or 1 cc thymus oil essential 1/2% on the basis of sesame oil with 9 cc distilled water every 12 hours for 10 days nebulizer. Control group: 15 drops or 1 cc placebo (containing distilled water in the base of the oil Sesame) with 9 cc distilled water every 12 hours for 10 days nebulizer. Percentage of patients with ventilator associated pneumonia. Timepoint: CPIS measurements at the beginning of the study (before the intervention) and 5th and 10th days after the began of intervention. Method of measurement: Clinical Pulmonary Infection Score (CPIS). Peak inspiratory pressure and plateau pressure. Timepoint: at the beginning of the study (before the intervention) and 5th and 10th days after the began of intervention. Method of measurement: monitoring of ventilator data. SpO2, SaO2. Timepoint: at the beginning of the study (before the intervention) and 5th and 10th days after the began of intervention. Method of measurement: pulse oxymeter and arterial blood gas. Rapid Shallow Breathing Index (RSBI). Timepoint: at the beginning of the study (before the intervention) and 5th and 10th days after the began of intervention. Method of measurement: monitoring of ventilator data. Shahed University Approved 2017-08-13 Ethics committee of Shahed University Shahed University, Opposite Holy Shrine of Imam Khomeini, Khalij Fars Expressway, P.O. Box 18155/159, Tehran, Iran Tehran Chahar-Mahal-va-Bakhtiari Iran (Islamic Republic of)