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IRCT2017031133014N1 IRCT 2017-09-06 Vice chancellor for research, Ahvaz Jundishapur University of Medical Sciences The effect of vitamin D in vitiligo patients - The effectiveness of vitamin D compared with placebo in vitiligo patients treated with Narrow Band UVB: A randomized control trial 2017-07-23 anticipated 24 Complete https://irct.ir/trial/25575 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Other design features: Randomization will be performed through block randomization method with the blocks of 6. In this method, the randomization will be done until the third person will be randomly assigned to a group, after which the individuals will be allocated to the other group automatically until the 6th blocks will be completed. 1 Vitiligo. Intervention 1: Intervention group: Pearl VIT D 50000 unit, Orally, on pearl every 2 weeks, for 2 months Plus Narrow Band UVB, 0.3 J / CM2. Intervention 2: Control group: Placebo, Orally, Every 2 weeks a number for 2 months Plus Narrow Band UVB, 0.3 J / CM2.
public Dr Zahra ALsadat Mousavi
Skin Ward, Imam Khomeini Hospital, 24 Metry Street, Ahvaz
Ahvaz Iran (Islamic Republic of) 6193673166 +98 21 2245 6080 nafmousavi@gmail.commousavi.z@ajums.ac.ir Skin Ward, Ahvaz Imam Khomeini Hospital scientific Dr Mohammad Omidian
Skin Ward, Imam Khomeini Hospital, 24 Metry Street, Ahvaz
Ahvaz Iran (Islamic Republic of) 6193673166 +98 612222922 momidian@yahoo.com Skin Ward, Ahvaz Imam Khomeini Hospital Iran (Islamic Republic of) Inclusion criteria: patients with generalized vitiligo or skin lesions equal or more than five percent of the body surface. Exclusion criteria: patients with hemodialysis and renal failure; receiving thiazide diuretics, lithium utilization; get systemic treatment in the last month; increasing serum leading to drug toxicity; age under 6 years old; phototherapy sessions less than 2 times a week. 6 years no limit Both L80 Vitiligo Treatment - Drugs Treatment - Drugs Intervention group: Pearl VIT D 50000 unit, Orally, on pearl every 2 weeks, for 2 months Plus Narrow Band UVB, 0.3 J / CM2. Control group: Placebo, Orally, Every 2 weeks a number for 2 months Plus Narrow Band UVB, 0.3 J / CM2. Changes in the extent of skin involvement. Timepoint: Every 2 months until 4 months. Method of measurement: Based on Vitiligo Area Scoring Index (VASI) Score. In this method body is divided into five separate regions: the hands, upper extremities, trunk,lower extremities and feet. The face and neck areas are assessed separately. One hand unit of the patient (the palm plus the volar surface of the digits) is used as a guide to estimate the baseline percentage of vitiligo involvement of each body region. For each body region, VASI is determined as the product of the vitiligo area in hand units (set at 1% per unit) and the pattern of depigmentation within each hand-unit-measured patch (possible values of 10, 25,50, 75, 90 or 100%, which are illustrated with a descrip-tive atlas of patient photographs). VASI, applied to the whole body, will calculated using the following formula, (possible range 0–100): all body sites (hand units) × depigmentation. Serum 25-hydroxyvitamin D level. Timepoint: At the beginning and at the 11th week of the study. Method of measurement: Blood test. Vice chancellor for research, Ahvaz Jundishapur University of Medical Sciences Approved 2016-12-27 Ethics committee of Ahvaz Jundishapur University of Medical Sciences Vice chancellor for research, Ahvaz Jundishapur University of Medical Sciences, Golestan street, Shahre Daneshgahi, Ahvaz Ahvaz Iran (Islamic Republic of)