IRCT20170428033670N1 IRCT 2018-01-21 Immunology Research Center of Shahed University Effect of Zingiber zerumbet pomade in treatment of knee arthrosis Comparison of the Effectiveness of Zingiber zerumbet ointment with Diclofenac Gel on clinical symptoms in patients with Knee osteoarthritis: A randomized, double-blind, controlled trial 2018-01-31 anticipated 80 Complete https://irct.ir/trial/25913 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: The allocation of patients to Drug and Positive Control Groups, will be done by block randomization method. Zingiber Zerumbet (ZZ) Ointment and diclofenac gel are packed in completely similar containers and in weight; Each container is identified by a code. The code and contents of containers will be recorded by a third party in a sheet. The drugs are available to the researcher in the binary blocks of ZZ and diclofenac and ultimately distributed among the patients, the investigator and the patient are not aware of the contents of the packages, Blinding description: The drug containers are encoded with the same shape and weight, and are given to the researcher in binary blocks, and then given to the patient; the patient, the investigator, and the analyst in the study are blinded; The medications, are indicated for the data analyst as drug A and drug B. 3 Osteoarthritis. Intervention 1: zingiber zerumbet pomade, Knee local use. Dosage 1 grams per use 4 times a day. Intervention 2: Plus control group: diclofenac gel group. Knee local use. Dosage 1 grams per use4 times a day. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is I currently do not have a specific program to share data, but I will do this in the future.