IRCT2017052634053N2 IRCT 2017-07-13 Hamadan University of Medical Sciences The use of stem cells for the treatment of the cartilage lesions Comparison of Transplantation of Mesenchymal Stem Cells and Autologous Chondrogenic Pre-Differentiated Mesenchymal Stem Cells for the Treatment of Cartilage Lesions of knee joint 2017-08-23 anticipated 16 Complete https://irct.ir/trial/26140 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment. N/A Destructive lesions of the knee joint cartilage. Intervention 1: Control group: This group will receive only autologous mesenchymal stem cells. One to two million cells are spilled in the alginate bed and the medium is changed every three days until the alginate is saturated with the MSCs. Alginate will then be transplanted into the affected area. Alginate volume is determined based on the amount of damage space. Intervention 2: Intervention group: This group receives autologous chondrogenic pre-differentiated mesenchymal stem cells (MSCs). One to two million cells are spilled in the alginate bed and the medium is changed every three days until the alginate is saturated with the MSCs. Then we use induced media to differentiate the cells. When they induced to autologous chondrogenic pre-differentiated, the alginate containing these cells will be transplanted into the affected area. Alginate volume is determined based on the amount of damage space.