IRCT2017052734154N1 IRCT 2017-06-30 Vice chancellor for Research and Technology, Islamic Azad University of Shahrood The efficacy of Doxycycline – Rifampin – Gentamicin, Doxycycline – Rifampin– Ciprofloxacin and Doxycycline – Co-trimoxazole – Gentamicin in complicated brucellosis Comparison of the efficacy of three drug regimens Doxycycline – Rifampin – Gentamicin, Doxycycline – Rifampin– Ciprofloxacin and Doxycycline – Co-trimoxazole – Gentamicin on relapse of disease in patients with complicated brucellosis: A clinical trial 2017-06-22 anticipated 75 Complete https://irct.ir/trial/26175 interventional Randomization: Randomized, Blinding: Not blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment. 3 Brucellosis. Intervention 1: Intervention group: Doxycycline 100 mg PO BID and Rifampicin 600 mg IV daily and PO after discharge and Gentamicin 80 mg IV TDS and Streptomycin 1 gr IM after discharge. This regimen prescribed for 6 months. Intervention 2: Intervention group: Doxycycline 100 mg PO BID and Rifampicin 600 mg IV daily and PO after discharge and Ciprofloxacin 400 mg IV and 500 mg PO BID after discharge. This regimen prescribed for 6 months. Intervention 3: Intervention group: Doxycycline 100 mg PO BID and Co-trimoxazole (trimethoprim 80 mg/5ml and sulfamethoxazole 400 mg/5 ml IV BID and PO after discharge and Gentamicin 80 mg IV TDS and Streptomycin 1 gr IM after discharge. This regimen prescribed for 6 months.