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IRCT138902081159N2 IRCT 2010-10-16 Isfahan University of Medical Sciences Comparative study of topical TCA %50 and cultured autologous fibroblasts in the treatment of the atrophic scars of face.(Pilot Study) Comparative study of topical TCA %50 and cultured autologous fibroblasts in the treatment of the atrophic scars of face. (Pilot Study) 2010-05-22 anticipated 20 Complete https://irct.ir/trial/263 interventional Randomization: Randomized, Blinding: Single blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment. 0 (exploratory trials) atrophic scar. Intervention 1: TCA 50%, topical, once monthly for 3 months. Intervention 2: Autologous fibroblasts (20million/mL), three times with 1-2 weeks intervals.
public Dr Mohamad Ali Nilforushzade
Skin Diseases and Leishmaniasis Research Center, Third Floor, Sedigheh Tahereh Research Centers, Next to Shahidan Square, Khoram Street, Isfahan, Iran
Isfahan Iran (Islamic Republic of) +98 31 1337 7767 Sdlrc@mui.ac.ir Skin Disease and Leishmaniasis Research Center (Sedigheh Tahereh) scientific Dr Mohamad Ali Nilforushzade
Skin Diseases and Leishmaniasis Research Center, Third Floor, Sedigheh Tahereh Research Centers, Next to Shahidan Square, Khoram Street, Isfahan, Iran
Isfahan Iran (Islamic Republic of) +98 31 1337 7767 Sdlrc@mui.ac.ir Skin Disease and Leishmaniasis Research Center (Sedigheh Tahereh) Iran (Islamic Republic of) Inclusion criteria: Age more than 18 years, dissatisfaction of facial appearance, Negative pregnancy test at the screening visit, signing written informed consent, compliance with the study requirements, Healthy, non-scarred skin for biopsy Exclusion Criteria: Previous treatment with dermal filler or other method, participating in another clinical trial, History of autoimmune disease or organ transplantation, History of cancer, Active systemic infection, need to chronic antibiotic or steroidal therapy, Using systemic agents that increase bleeding or clotting, any disorder that increase bleeding or clotting, Pregnancy or breast feeding, Known allergic reaction to components of study treatment and/or study injection procedure, Excessive exposure to sun or sunburn in the post-auricular area, Patients with psychological disorders 18 years 80 years Both L90.5 Scar conditions and fibrosis of skin Treatment - Drugs Treatment - Drugs TCA 50%, topical, once monthly for 3 months. Autologous fibroblasts (20million/mL), three times with 1-2 weeks intervals Scar size. Timepoint: before and after the intervention. Method of measurement: Photography of scar before beginning of the study and millimeter paper. Cinical improvement of scar. Timepoint: Before the study and 3, 6, and 12 months after the beginning of study. Method of measurement: Photography of scar at each visit. Isfahan University of Medical Sciences Approved Isfahan University of Medical Sciences Hezar Jarib Boulevard, Isfahan, Iran Isfahan Iran (Islamic Republic of)