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IRCT2017061734582N1 IRCT 2017-07-23 zahdan university of medical siences Effect of ciprofloxacin on advanced chronic periodontitis Evaluation the effect of adjuvant therapy with ciprofloxacin in non-surgical treatment of sever chronic periodontitis 2017-06-22 anticipated 80 Complete https://irct.ir/trial/26395 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Other design features: This double-blind clinical and place be-controlled trial is conducted on the patients affected with severe chronic periodontist reoffering to the periodontics department of dentistry faculty of Zahedan University of medical Sciences . the patients , who keep the required conditions are involved into the study it they are satisfied studying the terms . In addition , the consent form is filled by the patient , while the following Indexes are measured in these patients and registered in their information from. Gingival bleeding index (GBI): In this method , each tooth is slowly probed in six places using a periodontal probe, mesial , mid and distal are scored on the both of Bacall and lingual surface , while bleeding is scored based on the presence or lack of presence of bleeding , as well the number of bleeding sites (14). Periodontal pocket Depth (PPD) : the distance between sulcus depth to gum margin of the available teeth , pocket depth in the mesiobuccally and dentilingual using Williams periodontal probe will be measured , wile factional measured , wile fractional measurements are rounded to the nearest number for one mm. Clinical attachment level : the distance between sulcus depth to CEJ of all the available teeth , CAL in the mesiobuccall surfaces , midbacal , Distobuccall, mesio lingual , midlingual , distolingual using Williams periodontal probe (hu-friedy , Chicago . IL ,USA), wile the mesurments are rounded to the nearest number for one mm. All of the patients will be completely scaled and root surface probed . hygiene training will be given to all of the patients same (tooth brushing , which is done based on the muddied Stallman method in the periodontal patients with reduction , while it will be done based on the bas method in the patients without reduction, as well use of dental floss). Of antimicrobial mouth wash during the study . After completion of SRP , the patients randomly divided in two equal test group and control group using Black randomization method . In this study , the medicine is provided by the plan executor for the researcher , who gives them to the patients while he does not know the delivered medicine type. In this study , two ciprofloxine antibiotic 500 mg (Dorou pakhsh company ) is given to the case group per day for 7 days. While , Darounama capsule (placebo ) is prescribed for the control group with same doze and day frequency . In this study , the patient and prescriber have no information about the consumption medicine . After starting the study . the patients refer to evaluate their hygiene status , as well measuring and registering clinical Indexes , while they are trained about hygiene . the amount of index plaque of all patients are kept less than ,25 percent . based on O’Leary index , However , it the patient involves a problem , will be excluded . these people not collaborate. It must be mentioned that ,all of the data will be registered by the same person. 2-3 sever chronic periodontitis. Intervention 1: In this study, for the case group, ciprofloxacin 500 milligrams of daroo pakhsh company were given two days daily for 7 days. Intervention 2: In this study, for the control group, placebo 500 milligrams of daroo pakhsh company were given two days daily for 7 days.
public dr.masood bamedi
dentistry zahdan university
zahdan Iran (Islamic Republic of) +98 54 3342 9519 e.kalvand@zaums.ac.ir dentistry zahdan university scientific dr.masood bamedi
dentistry zahdan university
zahdan Iran (Islamic Republic of) - +98 54 3342 9519 e.kalvand@zaums.ac.ir dentistry zahdan university Iran (Islamic Republic of) Inclusion Criteria :Age upper 18 years old؛ Presence of twenty teeth of least؛Affection with spread mean to severe chronic periodontitis At least (3-5 min clinical attachment loss in more thou 30 percent of the mouth areas . Exclusion criteria: Lack of patient’s coloration؛ Antibiotic therapy doing the third past months؛Allergy background for ciprofloxacin؛ Smoking people or addicted to tobacco؛ Affection with systemic diseases , which are effective on the periodontal conditions such as diabetes , blood disorders and immune system؛ Pregnant women؛ Periodical Intervention Performance during the third past months؛People who are under treatment with warfarin , antacid T and Cyclosporine. 18 years 60 years Both K05.3 Chronic periodontitis Chronic pericoronitis Treatment - Drugs Treatment - Drugs In this study, for the case group, ciprofloxacin 500 milligrams of daroo pakhsh company were given two days daily for 7 days In this study, for the control group, placebo 500 milligrams of daroo pakhsh company were given two days daily for 7 days Gingival bleeding index(GBI). Timepoint: the first, scond and fourth months. Method of measurement: bleeding-non bleeding. Probing depth(PD). Timepoint: the first, scond and fourth months. Method of measurement: Based on Periodontal Probe williams. Clinical attachment level(CAL). Timepoint: the first, scond and fourth months. Method of measurement: Based on Periodontal Probe williams. Drug. Timepoint: First month for 7 days, two capsules a day. Method of measurement: Based on the presence or absence of consumption. Time. Timepoint: the first, scond and fourth months. Method of measurement: Based on the onset of a therapeutic intervention. zahdan university of medical siences Approved 2016-06-05 zahdan university af medical siences zahdan university af medical siences zahdan Iran (Islamic Republic of) Approved 2010-08-20 zahedan university of medical siences zahedan university of medical siences zahdan Iran (Islamic Republic of)