]>
IRCT20170704034901N2 IRCT 2018-05-29 Birjand University of Medical Sciences investigation of probiotic effects on prophylaxis of pneumonia Investigation of probiotic effects on prophylaxis of ventilator – associated pneumonia in ICU patients 2018-03-21 anticipated 50 Complete https://irct.ir/trial/26548 interventional Randomization: Randomized, Blinding: Not blinded, Placebo: Not used, Assignment: Parallel, Purpose: Prevention, Randomization description: Simple randomization method , using the Random numbers table , individual randomization. N/A Ventilator associated pneumonia(VAP). Intervention 1: Intervention group: Patients receive the first dose of probiotics during the first 24 hours of intubation and, until extubation or up to 10 days after the intubation, every 12 hours, one tablet of vitalact (each tablet contains 10〗 9 CFU of lactobacillus gasseri, Bifidobacterium bifidum, Bifidobacterium longum and multivitamin And mineral. Of Iran's Bioscience Company). Intervention 2: Control group: This group does not take any special medication. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is No more information.
public Dr. Farshid Abedi
Birjand University of Medical Sciences, Ghaffari ave
Birjand Iran (Islamic Republic of) ۹۷۱۷۸۵۳۵۷۷ +98 56 3238 5600 abedifar@yahoo.com Birjand University of Medical Sciences scientific Dr. Farshid Abedi
Birjand University of Medical Sciences, Ghaffari ave
Birjand Iran (Islamic Republic of) ۹۷۱۷۸۵۳۵۷۷ +98 56 3238 5600 abedifar@yahoo.com Birjand University of Medical Sciences Iran (Islamic Republic of) age over than 18 year Length of stay in ICU for more than 5 days 18 years no limit Both Diarrhea at first visit or 48 hours before admission immune deficiency Regular treatment with probiotics before admission pregnancy J15 Bacterial pneumonia, not elsewhere classified Prevention Prevention Intervention group: Patients receive the first dose of probiotics during the first 24 hours of intubation and, until extubation or up to 10 days after the intubation, every 12 hours, one tablet of vitalact (each tablet contains 10〗 9 CFU of lactobacillus gasseri, Bifidobacterium bifidum, Bifidobacterium longum and multivitamin And mineral. Of Iran's Bioscience Company). Control group: This group does not take any special medication. The incidence of ventilator associated pneumonia(VAP). Timepoint: Up to 15 days after starting probiotics, ventilator-associated pneumonia will be examined. Method of measurement: Daily hematologic examination (CBC and neutrophil count), active phase proteins (CRP or proxlotonin or ferritin) and chest X ray, Based on the American College of Chest Physicians clinical criteria, new or sustained infiltration in the CXR with 2 or 3 of the following findings: fever (.38.58C or ,35.08C), leukocytosis (white bloodcells . 10,000/mm3 or ,3,000/mm3), and purulent sputum. Birjand University of Medical Sciences Approved 2018-02-06 Ethics Committee of Birjand University of Medical Sciences Birjand University of Medical Sciences, Ghaffari ave Birjand South Khorasan Iran (Islamic Republic of)