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IRCT20170723035247N1 IRCT 2018-01-03 Vice chancellor for resaerch Kashan University of Medical Sciences The effect of Ondansetron to tretment obsessive -copmpulsive disorder The effect of Ondansetron augmentation in tretment resistant obsessive-copulsive disorder 2017-06-22 anticipated 40 Complete https://irct.ir/trial/26690 interventional Randomization: N/A, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Blinding description: Blindness on the one hand is the lack of knowledge of the distributor's psychiatrist about the distribution of drugs among the patients, and the blind on the other side, which patients do not know the type of drug (ondansetron or placebo). The distribution of the medicine will be done by the nurse and the psychiatrist will examine the patients in terms of the scale of Yale-Brown. 3 Obsessive -compulsive disorder. Intervention 1: In the first intervention group: In addition to SSRIs, it is given ondansetron at an average dose of 8 mg per day for 2 weeks. Intervention 2: In the control group, with SSRIs, the patient will receive the same dose of placebo for 12 weeks as the original drug. Undecided - It is not yet known if there will be a plan to make this available

public Zahra sepehrmanesh MD

Ghotbe ravandi Blv. Kargarnejad hospital

Kashan Iran (Islamic Republic of) 8715973446 +98 31 5554 9111 Z.sepehrmanesh@yahoo.com Kashan University of Medical Sciences scientific Zahra Sepehrmanesh MD

Ghotbe Ravandi Blv. Kargarnead Hospital

Kashan Iran (Islamic Republic of) 8715973446 +98 31 5554 9111 z.sepehrmanesh@yahoo.com kashan University of Medical Science Iran (Islamic Republic of) Aged 18 years and over. Despite received at least three months of adequate and tolerable SSRI drugs, the scores of obsessive-compulsive scores 16 and up. No pregnancy or breastfeeding in women. No psychiatric disorder such as Bipolar in the axis 1 of psychiatry. Lack of mental retardation in the axis 2 of psychiatry. Lack of alcohol intake 6 months before the study. Lack of psychotherapy during the study. 18 years 60 years Both Acute and severe physical illness during the study. Non-follow-up for 4 weeks. Severe complications during treatment. Not using contraceptive methods in females F42 F42-The essential feature is recurrent obsessional thoughts or compulsive acts.obsessional thoughts are ideas,images,or impuses that enter the patients mind again and again in stereotyped form.They are , almost invariably distressing and the patient ofte Treatment - Drugs Treatment - Drugs In the first intervention group: In addition to SSRIs, it is given ondansetron at an average dose of 8 mg per day for 2 weeks. In the control group, with SSRIs, the patient will receive the same dose of placebo for 12 weeks as the original drug. Severity obsessive compulsion. Timepoint: Before the start of trial and every four weeks. Method of measurement: Yale Brown Obsessive -Compulsion Scala. Sudden drug effect. Timepoint: Before the start of the trial ,the end of the first-two-fourth-sixth-eighth-twelfth weeks. Method of measurement: Interviwe and examination. Vice chancellor for resaerch Kashan University of Medical Sciences Approved 2016-09-27 Kashan University of Medical Sciences ethic commetee in health sciences Medical college, Ghotb Ravandi boulevard, Kashan Kashan Isfehan Iran (Islamic Republic of)