IRCT201308181159N9 IRCT 2013-10-19 Vice Chancellor for Research, Tehran University of Medical Sciences Comparison of efficacy of laser Q-Switch 1,064 nm Nd: YAG with two different methods in the treatment of Malasma Comparison of the efficacy and safety of Q-Switch 1,064 nm Nd:YAG Laser with and without carbon photo enhancer lotion on reducing skin pigmentation in patients with Melasma referred to Skin and Stem cell research center of Tehran University of Medical Sciences 2013-12-22 anticipated 43 Complete https://irct.ir/trial/268 interventional Randomization: Randomized, Blinding: Not blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Other design features: According to this topic that patients with symmetric damages on the face will be entered into the study, right or left part of the face will randomly receive carbon solution through laser. 3 melasma. Intervention 1: Laser group with topical carbon: one half of face (A side) receives 3 sessions of Nd:YAG laser (fluence= 1.5-2 Joules per centimeter, spot size=7 Millimeters) with topical carbon at 1-week intervals followed by 3 same sessions at 2-week intervals. Intervention 2: Laser group without topical carbon: In the other side (B group), the same laser therapy will be administered at one half of face receives 3 sessions of Nd:YAG laser (fluence=1.5-2 Joules per centimeter, spot size=7 Millimeters) without topical carbon at 1-week intervals followed by 3 same sessions at 2-week intervals.