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IRCT2017081535716N1 IRCT 2017-09-22 - Changes of blood pressure and hemodynamic parameters after oral magnesium supplementation in patients with essential arterial hypertension Changes of blood pressure and hemodynamic parameters after oral magnesium supplementation in patients with essential arterial hypertension 2014-09-17 anticipated 48 Complete https://irct.ir/trial/26912 interventional Randomization: N/A, Blinding: Not blinded, Placebo: Not used, Assignment: Single, Purpose: Treatment, Other design features: None. N/A Essential (primary) hypertension. Daily oral supplementation with 300 mg of magnesium in the form of magnesium-oxide granules ("Magnezijum 300 Direkt" Hermes Arzneimittel GmbH, Germany) during one month at home. The granules were dissolved in the mouth with no liquid..
public Nikolina Banjanin
Dr Subotica 8
Belgrade Serbia and Montenegro 00381113612762 nikolina.banjanin@med.bg.ac.rs Institute of Hygiene and Medical Ecology, Faculty of Medicine, University of Belgrade scientific Nikolina Banjanin
Dr Subotica 8
Belgrade Serbia and Montenegro 00 381 11 3612762 nikolina.banjanin@med.bg.ac.rs Institute of Hygiene and Medical Ecology, Faculty of Medicine, University of Belgrade Serbia and Montenegro Inclusion criteria:age 24-65; essential arterial hypertention; unchanged antihipertensive therapy for at least one month; Exclusion criteria: renal diseases, gastrointestinal diseases, diabetes mellitus, diseases od adrenal, thyroid and parathyroid glands, angina pectoris, congestive heart failure, aortic coarctation, food and drugs allergy, pregnancy, lactation, myocardial infarction, coronary revascularisation, transitory ischemic attack, oral intake of magnesium supplements in the last one month 24 years 65 years Both I10 High blood pressure, Hypertension (arterial)(benign)(essential)(malignant)(primary)(systemic) Treatment - Other Daily oral supplementation with 300 mg of magnesium in the form of magnesium-oxide granules ("Magnezijum 300 Direkt" Hermes Arzneimittel GmbH, Germany) during one month at home. The granules were dissolved in the mouth with no liquid. Blood pressure (mm Hg). Timepoint: Before and after intervention. Method of measurement: Sphygmomanometer and Impedance cardiography. Heart rate (beats per minute). Timepoint: Before and after intervention. Method of measurement: Impedance cardiography. Thoracic fluid content (L/kOhm). Timepoint: Before and after intervention. Method of measurement: Impedance cardiography. Stroke Volume (mL). Timepoint: Before and after intervention. Method of measurement: Impedance cardiography. Stroke index (mL/m2). Timepoint: Before and after intervention. Method of measurement: Impedance cardiography. Cardiac output (L/min). Timepoint: Before and after intervention. Method of measurement: Impedance cardiography. Cardiac index (L/(min*m2). Timepoint: Before and after intervention. Method of measurement: Impedance cardiography. Acceleration index (L/100/s2). Timepoint: Before and after intervention. Method of measurement: Impedance cardiography. Left cardiac work index (kg*m/m²). Timepoint: Before and after intervention. Method of measurement: Impedance cardiography. Systemic vascular resistance index (dyn*s*m2/cm5). Timepoint: Before and after intervention. Method of measurement: Impedance cardiography. -. Timepoint: -. Method of measurement: -. - - - Approved 2015-07-01 Ethics Committee of the Faculty of Medicine, University of Belgrade Dr Subotica 8 Belgrade Serbia Serbia and Montenegro Approved 2014-09-16 Ethics Committee of the Clinical Center Of Serbia Pasterova 2 Belgrade Serbia Serbia and Montenegro