IRCT2017100336539N1 IRCT 2017-11-08 Shahid Sadoughi University of Medical Sciences Yazd The effect of vitamin D on the treatment of type 2 diabetes The effect of vitamin D injection on Endothelial Biomarker, hs-CRP, Lipid profile and Glycemic Control in vitamin D deficient patients with Type 2 Diabeties 2017-10-23 anticipated 50 Complete https://irct.ir/trial/27282 interventional Randomization: Randomized, Blinding: Not blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Other design features: Random number table. N/A Type II diabetes. Intervention: injection of Vitamin D 400000 IU first and one month after the start of the study each time 200,000 IU Duration of study 2 months. The control group does not receive anything..

public FARHANG MIRZAVANDI

Central Building of Shahid Sadoughi University of Medical Sciences, Bahonar Square, Yazd, Iran

Department of Nutrition, Faculty of Public Health, Shahid Sadughi University of Medical Sciences, Al Iran (Islamic Republic of) 8915173160 +98 35 3820 9143 f.mirzavandi@ssu.ac.ir farhangfm@yahoo.com Shahid Sadoughi University of Medical Sciences and Health Services Yazd scientific Dr hassan mozaffari-khosravi

Department of Nutrition, Faculty of Public Health, Shahid Sadughi University of Medical Sciences, Alem Square, Yazd, Iran.

Yazd Iran (Islamic Republic of) 8915173160 +98 353538209143 mozaffari.kh@gmail.com Shahid Sadoughi University of Medical Sciences, Yazd, Iran Iran (Islamic Republic of) inclusion: Diabetes mellitus patients and HbA1c hemoglobin less than 9 percent 2-25 levels of hydroxyvitamin D (25 OHD) less than 20 ng / ml 3- Age range 30-60 years and Exclusion criteria:1 - Lack of interest in participating in the study-2-Use of vitamin D supplementation over the past 3 months-3-Kidney,liver disease,Malabsorption syndrome,Severe infection-4-Use of immunosuppressive drugs-5- Pregnancy and lactation- 6- Use of insulin 30 years 60 years Both E11 Non-insulin-dependent diabetes mellitus Treatment - Drugs Intervention: injection of Vitamin D 400000 IU first and one month after the start of the study each time 200,000 IU Duration of study 2 months. The control group does not receive anything. E-Selectin of serum. Timepoint: Before the intervention and two months after the start of the study. Method of measurement: ELISA method. High-sensitivity C-reactive protein (hs-CRP) of serum. Timepoint: Before the intervention and two months after the start of the study. Method of measurement: ELISA method. Serum fasting blood sugar(FBS). Timepoint: Before the intervention and two months after the start of the study. Method of measurement: Enzymatic method. Vitamin D of serum. Timepoint: Before the intervention and two months after the start of the study. Method of measurement: ELISA method. Serum total cholesterol. Timepoint: Before the intervention and two months after the start of the study. Method of measurement: Enzymatic method. Serum triglyceride level (TG). Timepoint: Before the intervention and two months after the start of the study. Method of measurement: Enzymatic method. Serum high density lipoprotein cholesterol (HDL-C). Timepoint: Before the intervention and two months after the start of the study. Method of measurement: Enzymatic method. Serum low Density Lipoprotein cholesterol (LDL-C). Timepoint: Before the intervention and two months after the start of the study. Method of measurement: Enzymatic method. Serum Calcium. Timepoint: Before the intervention and two months after the start of the study. Method of measurement: Enzymatic method. Serum Phosphorus. Timepoint: Before the intervention and two months after the start of the study. Method of measurement: Enzymatic method. Weight. Timepoint: Before the intervention and two months after the start of the study. Method of measurement: by body Calibrated scale. Body mass index. Timepoint: Before the intervention and two months after the start of the study. Method of measurement: by body Calibrated scale. Body fat percent. Timepoint: Before the intervention and two months after the start of the study. Method of measurement: by body Calibrated scale. Muscle mass percent. Timepoint: Before the intervention and two months after the start of the study. Method of measurement: by body Calibrated scale. Visceral fat percent. Timepoint: Before the intervention and two months after the start of the study. Method of measurement: by body Calibrated scale. Evalution of patients diet. Timepoint: Before the intervention and two months after the start of the study. Method of measurement: Three-day food record. Shahid Sadoughi University of Medical Sciences Yazd Approved 2017-08-06 Shahid Sadoughi University of Medical Sciences Yazd Yazd - Alam Square - Anonymous Martyrs Blvd - Campus of Shahid Sadoughi University of Medical Sciences Yazd - Yazd School of Public Hea Yazd Iran (Islamic Republic of)