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IRCT20171104037209N1 IRCT 2017-11-29 Esfahan University of Medical Sciences A Comparative Study on the Effect of Prescribing Dexmedetomidine with Haloperidol in Preventing Delirium A Comparative Study on the Effect of Prescribing Dexmedetomidine with Haloperidol in Preventing Delirium after Coronary Artery Bypass Graft surgery in Chamran Hospital، 2016-2017 2016-10-22 anticipated 100 Complete https://irct.ir/trial/27575 interventional Randomization: Not randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Crossover, Purpose: Prevention, Blinding description: We made patients aware of the intervention، but without knowing which drug they would receive، each patient was given a number، According to even or odd receive either dexmedetomidin or haloperidol. 2-3 ِDelirium. Intervention 1: Intervention group: were put under dexmedetomidine 1 microgram per kilogram during 10 minutes and preserver infusion of 0.2 to 0.7 Micrograms per hour per kilogram until the separation of the ventilator andwere put under intramuscular haloperidol 0.5 mil. Intervention 2: Control group: were put under intramuscular haloperidol 0.5 milligram in case of agitation. Undecided - It is not yet known if there will be a plan to make this available
public Dr Gholamreza Masoumi
Third moshtagh st, bozorgmehr bridge, shahid chamran hospital
esfahan Iran (Islamic Republic of) 8166173414 +98 31 3260 0961 massoumigh@mui.ac.ir Esfahan University of Medical Sciences scientific Dr Gholamreza Masoumi
Third moshtagh st, bozorgmehr bridge , Chamran Heart Hospital
esfahan Iran (Islamic Republic of) 8166173414 +98 31 3260 0961 massoumigh@mui.ac.ir Esfahan University of Medical Sciences Iran (Islamic Republic of) The entrance criterion included the patients who were candidates for open surgery of coronary arteries and referred to Shahid Chamran Hospital participate in the study And were free from any psychiatric disease or dementia He candidates had agreed to participate in the study 18 years 80 years Both lack of candidate’s assistance Shortages in data under study The patient’s death during the surgery or by entrance to ICU Need to do the surgery again due to bleeding after entrance to ICU Excessive allergy to haloperidol and phenothiazine Parkinson (trembling at the time of rest) and weakness in CNS Glaucoma Seizure anamnesis Getting anti-seizure, anti-Parkinson, or lithium drugs F05.8 Other delirium Delirium of mixed origin Postoperative delirium Treatment - Drugs Treatment - Drugs Intervention group: were put under dexmedetomidine 1 microgram per kilogram during 10 minutes and preserver infusion of 0.2 to 0.7 Micrograms per hour per kilogram until the separation of the ventilator andwere put under intramuscular haloperidol 0.5 mil Control group: were put under intramuscular haloperidol 0.5 milligram in case of agitation Delirium، Delirium Exposure، Blood Pressure، During Hospital Occupation، Laboratory variables (sodium and potassium، and variables ABG). Timepoint: Before entering ICU، Before the pump، During the pump، After the pump، The first day of the ICU، The second day of the ICU، Third day of the ICU. Method of measurement: Delirium demonstration by the Richmond Agitation-Sedation Scale Severity of delirium using CAM-ICU Duration of the pump in minutes using the timer The duration of admission to the ICU by day using the count of the days Average arterial blood pressure using a mercury pressure gauge device Receiving haloperidol in the event of delirium with patient file information The amount of pack cell received using patient file information Laboratory variables through blood sampling and determination of laboratory values. Esfahan University of Medical Sciences Approved 2016-02-24 Ethics committee of Isfahan School of Medical Sciences Thousand Jereeb St. Isfahan University of Medical Sciences and Health Services, Faculty of Medicine esfahan Isfehan Iran (Islamic Republic of)