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IRCT20171105037245N1 IRCT 2017-12-09 Vice chancellor for research, Kashan University of Medical Sciences Comparison of the effect of two therapies methylphenidate and matrix-methylphenidate in methamphetamine abusers Comparison of the effect of two therapies methylphenidate and matrix-methylphenidate on the severity of addiction, craving and treatment abstinence in methamphetamine abusers 2017-10-14 anticipated 100 Complete https://irct.ir/trial/27600 interventional Randomization: Randomized, Blinding: Not blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: Randomization will be performed with simple method and random numbers generated by computer software (Stat Trek software) which choose the random numbers. N/A Methamphetamine Dependency. Intervention 1: The Matrix program, which consists of 22 sessions of cognitive and behavioral psychotherapy, will be performed weekly in two sessions of forty five minutes for 12 weeks. Intervention 2: Methylphenidate ( Ritalin ) will be given 10 mg per day in first month, 7.5 mg per day for second month and 5 mg per day for third month. Intervention 3: Combining matrix and methylphenidate treatment (The Matrix program, which consists of 22 sessions of cognitive and behavioral psychotherapy, will be performed weekly in two sessions of forty five minutes for 12 weeks and methylphenidate ( Ritalin ) will be given 10 mg per day in first month, 7.5 mg per day for second month and 5 mg per day for third month). Intervention 4: Control group (not receiving any psychological educational services and drugs). Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is Undecided - It is not yet known if there will be a plan to make this available
public Abdollah Omidi
Ghotbe Ravandi Boulevard, Kashan
Kashan Iran (Islamic Republic of) 8715988141 +98 31 5554 2999 omidi-a@kums.ac.ir Kashan University of Medical Sciences scientific Abdollah Omidi
Ghotbe Ravandi Boulevard, Kashan
Kashan Iran (Islamic Republic of) 8715988141 +98 31 5554 2999 omidi-a@kums.ac.ir Kashan University of Medical Sciences Iran (Islamic Republic of) being at the age of 20 to 48 years Methamphetamine dependence diagnoses accordingly Diagnostic and Statistical Manual of Mental Disorders fifth edition The dominant use of methamphetamine Seeking treatment for methamphetamine abuse 20 years 48 years Both Unwillingness to participate in the study Having severe psychotic disorders Suicide attempts within the past 12 months Major cardiovascular disorder Epilepsy Current alcohol or sedative physical dependence or cocaine dependence F15.15 Other stimulant abuse with stimulant-induced psychotic disorder Behavior Treatment - Drugs Treatment - Other N/A The Matrix program, which consists of 22 sessions of cognitive and behavioral psychotherapy, will be performed weekly in two sessions of forty five minutes for 12 weeks. Methylphenidate ( Ritalin ) will be given 10 mg per day in first month, 7.5 mg per day for second month and 5 mg per day for third month Combining matrix and methylphenidate treatment (The Matrix program, which consists of 22 sessions of cognitive and behavioral psychotherapy, will be performed weekly in two sessions of forty five minutes for 12 weeks and methylphenidate ( Ritalin ) will be given 10 mg per day in first month, 7.5 mg per day for second month and 5 mg per day for third month) Control group (not receiving any psychological educational services and drugs) Addiction Severity. Timepoint: At the beginning of the study and after 12 weeks of intervention. Method of measurement: Addiction Severity Index. Craving. Timepoint: At the beginning of the study and after 12 weeks of intervention. Method of measurement: Desire for Drug Questionnaire (DDQ craving). Mental health. Timepoint: At the beginning of the study and after 12 weeks of intervention. Method of measurement: General Health Questionnaire (GHQ). Negative urine test for methamphetamine. Timepoint: Before intervention and 3, 6, 9 and 12 weeks after intervention. Method of measurement: Methamphetamine urine test. Vice chancellor for research, Kashan University of Medical Sciences Approved 2017-10-12 Ethics committee of Kashan University of Medical Sciences Ghotbe Ravandi Boulevard, Kashan Kashan Isfehan Iran (Islamic Republic of)