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IRCT20171112037401N3 IRCT 2018-02-01 Mashhad University of Medical Sciences ,Vice chancellor for research Comparison of the Effect of "Herbal Ointment " with" Methyl Salicylate Ointment " in patients with knee arthritis Comparison of the Effect of "Herbal ointment (Ginger, Black Pepper and Rose)" with "Methyl Salicylate ointment" on Improving pain and functional disorders in patients with knee arthritis 2017-12-21 anticipated 80 Complete https://irct.ir/trial/27681 interventional Randomization: Randomized, Blinding: Triple blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Other design features: Herbal medicine design with Iranian medicine approach, Randomization description: Simple randomization, Blinding description: The participant - investigator - the outcome evaluation - the outcome of the safety committee and the data monitoring committee do not know what kind of ointment. 3 Knee Osteoarthritis. Intervention 1: Intervention group 1: prescribing herbal ointment containing the juice of three plants: pepper, cinnamon, and roses with equal ratio in a base of animal oil lubricant base, will give to three doses daily for two months. Ointment is made at the Mashhad Faculty of Traditional Medicine. Intervention 2: Intervention group 2: Methyl salicylate ointment 30 g (each 100 g contain 15 g of methyl salicylate and 10 g of menthol) made by Sobhan-Dar company is given in three daily doses for two months. the results showed that the pain variable in the vegetation group was decreased from ( 1 / 45 / 45 ) to 42 / 35 / 4 ) and the intensity of pain was decreased from ( 1 / 1 f / 3 ) to ( 11 / 1 / 12 ) . In the METHYL SALICYLATE ointment consumer group , the pain variable ( 81 ± 55 ± 77 / 8 ) was reduced to ( ± 1.0 ± 2 ± 7 / 7 ) and the intensity of the pain variable ( 89 ± 0.6 ± 85 ) and the pain intensity variable ( 99 ± 0.6 ± 55 ) to 71 ± 1.0 ± 1 / 4 ) . Therefore the test result was significant for all three variables ( 00 / 00 P ) . On the other hand ,On the other hand , according to Fisher 's careful examination of pain and the use of herbal ointment as well as a synthetic ointment was positive (p= 001 /0) However , no significant relationship was observed when using METHYL SALICYLATE ointment ( 07 / p = p ) . In fact , the reduction in pain is the positive effect of drug ointment on the intensity and intensity of pain , which was significant at the same time in all three groups ; but in the group using herbal ointment ( pain and intensity of pain 3 ) , it was ranked And in the group using METHYL SALICYLATE ointment , it had the last rank ( pain of 2 units and intensity of pain close to 1 unit ) In terms of descriptive statistics , in fact , in the compound group 13 out of 20 people finally preferred the use of herbal ointment . It is not expected that the result of the test in all three meaningful groups is not unexpected because the nature of METHYL SALICYLATE was decreased in pain and in line with our study , but it was important to the researcher of the value and effect size , which had less influence than herbal ointment . According to researchers from other research banks , it is not found to compare the effect of herbal ointment with methyl salicylate ( Comparison of housing effect effect of ginger and pepper and roses with methyl salicylate ) , so the use of this ointment may also be effective in reducing the pain and intensity of pain . But if this study is carried out in larger sample volumes and in larger treatment centers and by other researchers on patients with different conditions , these findings will be reliable and reliable . Conclusion based on the findings of this study , topical application of herbal ointment introduced in this study reduces pain and severity of people knee pain compared to METHYL SALICYLATE , so it is advisable to use this ointment in the pharmaceutical industry after studies and further research . Table 1 : Comparison of the effect of METHYL SALICYLATE ointment and herbal ointment on pain and intensity of pain variables group frequency mean deviation of the test result herbal ointment pain prior to use 40 45/8 17/1 group variables frequency mean deviation result of the test herbal ointment Pain before use 40 8/45 1/17 0/00 Pain After Use 40 4/35 1/42 The intensity of pain before using 40 7/40 1/19 The intensity of pain after using 40 3/12 1/11 Changes in pain grade 40 -4/10 0/98 Changes to pain intensity score 40 -4/28 1/21 METHYL SALICYLATE Pain before use 40 8/55 0/81 0/00 Pain After Use 40 6/77 1/02 The intensity of pain before using 40 7/85 0/89 The intensity of pain after using 40 7/20 1/09 Changes in pain grade 40 -1/77 0/97 Changes to pain intensity score 40 -0/65 0/69 Use both oitment at the same time Pain before use 40 8/60 0/94 0/00 Pain After Use 40 5/55 1/57 The intensity of pain before using 40 7/55 0/99 The intensity of pain after using 40 4/10 1/71 Changes in pain grade 40 -3/05 0/88 Changes to pain intensity score 40 -3/45 1/66 Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is The investigation has not been done
public Mohammad Sabbaghi
Shirudi street 16-18The Center for Health17shahrivar
Mashad Iran (Islamic Republic of) 9167763643 +98 51 3364 7827 sabbaghim2@mums.ac.ir Mashhad University of Medical Sciences scientific Mohammadreza Noras
Mashhad University of Medical Sciences -Mashhad Faculty of Traditional Medicine
Mashhad Iran (Islamic Republic of) norasmr@mums.ac.i +98 51 3855 2189 norasmr@mums.ac.ir Mashhad Faculty of Traditional Medicine Iran (Islamic Republic of) Symptomatic primary osteoarthritis in knee approved by clinical or radiological criteria Pain: Score over 40 (Visual Scale) Age: 60 - 80 years 60 years 80 years Both Patient dissatisfaction Drug use Patients treated with hormonal drugs m17.9 Gonarthrosis Treatment - Drugs Treatment - Drugs Intervention group 1: prescribing herbal ointment containing the juice of three plants: pepper, cinnamon, and roses with equal ratio in a base of animal oil lubricant base, will give to three doses daily for two months. Ointment is made at the Mashhad Faculty of Traditional Medicine. Intervention group 2: Methyl salicylate ointment 30 g (each 100 g contain 15 g of methyl salicylate and 10 g of menthol) made by Sobhan-Dar company is given in three daily doses for two months. Joint stiffness. Timepoint: Two weeks after start the treatment, then every two weeks for two months. Method of measurement: WOMAC questionnaire. Pain. Timepoint: Two weeks after start the treatment, then every two weeks for two months. Method of measurement: The VAS criterion. Physical action. Timepoint: Two weeks after start the treatment, then every two weeks for two months. Method of measurement: WOMAC questionnaire. Dissatisfaction. Timepoint: Two weeks after start the treatment, then every two weeks for two months. Method of measurement: Discontinue the treatment. Mashhad University of Medical Sciences ,Vice chancellor for research Approved 2017-07-15 Ethics committee of Mashhad University of Medical Sciences University Avenue, Building Qureshi, research and technology Mashhad University of Medical Sciences Mashhad Razavi Khorasan Iran (Islamic Republic of)