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IRCT20171117037512N2 IRCT 2018-02-22 Mazandaran University of Medical Sciences Comparing the efficacy of permethrin and dimethicone in treatment of head lice infestation Comparing the efficacy of permethrin 1% and dimethicone 4% in treatment of primary school girls with head lice infestation: a clinical trials 2018-02-20 anticipated 90 Complete https://irct.ir/trial/27720 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: This study is a double blind randomized clinical trial carried out among 90 patients with pediculosis infestation. These patients will be allocated to permethrin 1%(Gilaranco, Rasht, Iran) and dimethicone 4%(Salmi Daru co, Tehran, Iran, IRC: 1228136177) treatment groups using block randomization by means of random allocation software, Blinding description: Both drugs will be covered with similar boxes for blinding reason.This action is enough to blind patients because the shampoo is consumed at home. The outcome evaluators will also be blinded. 4 Head lice. Intervention 1: Group 1 intervention: In the treatment group with dimethicone, lotion dimethicone 4% will be pealed around the hairs from the root to the top. It should be normally dried and stayed at least eight hours or one night. Intervention 2: Control group: In the treatment group with permethrin 1%, first, hairs will be washed by another shampoo and dried. Then, all hairs as well as the scalp should be completely covered with appropriate amount of permethrin 1% shampoo for 10 minutes and then, will be washed with water. Yes - There is a plan to make this available What will be shared: All data will be shared. When: After publishing the results. To whom: Researchers working in academic institutions. Conditions: To be applied as a data bank for IPD meta-analysis. Where to obtain: Via e-mail to corresponding author mmoosazadeh1351@gmail.com How to obtain: The data will be sent after 10 days. Comments:
public Mahmood Moosazadeh
Moallem square-sari
Sari Iran (Islamic Republic of) 4851676789 +98 11 3325 7230 mmoosazadeh1351@gmail.com Mazandaran University of Medical Sciences scientific Mahmood Moosazadeh
Moallem square
Sari Iran (Islamic Republic of) 4851676789 +98 11 3325 7230 mmoosazadeh1351@gmail.com Mazandaran University of Medical Sciences Iran (Islamic Republic of) Female gender age between 6 and 13 years being infected with head lice having normal general condition 6 years 13 years Female History of any sensitivity to anti-pediculosis drugs Dermatologic disorders Secondary bacterial infection Scalp burning Asthma Using hair care products Using anti-pediculosis drugs during the last seven days B85.0 Pediculosis due to Pediculus humanus capitis Treatment - Drugs Treatment - Drugs Group 1 intervention: In the treatment group with dimethicone, lotion dimethicone 4% will be pealed around the hairs from the root to the top. It should be normally dried and stayed at least eight hours or one night. Control group: In the treatment group with permethrin 1%, first, hairs will be washed by another shampoo and dried. Then, all hairs as well as the scalp should be completely covered with appropriate amount of permethrin 1% shampoo for 10 minutes and then, will be washed with water. Cure rate in each group as no evidence of any adult lice, nymph or egg. Timepoint: Before intervention, days 7, 14 and 21. Method of measurement: Examination of samples by an expert medical entomologist. Dermal and periorbital allergic reactions. Timepoint: Before intervention, days 7, 14 and 21. Method of measurement: Sample examination. Mazandaran University of Medical Sciences Approved 2015-10-05 Ethics committee of Mazandaran University of Medical Sciences Mazandaran-Sari Sari Mazandaran Iran (Islamic Republic of)