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IRCT20170925036401N1 IRCT 2017-12-07 Rasht University of Medical Sciences effect of eptifibatide and reteplase on primary angioplasty outcomes Comparison of the efficacy of intracoronary and intravenous Eptifibatide and intracoronary Retaplase on coronary blood flow in patients undergoing PPCI at Dr.Heshmat hospital during 2017-2018 (Randomized clinical trial study) 2017-12-01 anticipated 160 Complete https://irct.ir/trial/27756 interventional Randomization: Randomized, Blinding: Not blinded, Placebo: Not used, Assignment: Other, Purpose: Treatment, Randomization description: random block. N/A Acute Myocardial Infarction. Intervention 1: Intervention group: Group 1: Patients who have a stent after thrombosuction. Intervention 2: Intervention group:Group 2: Patients who receive 180 microgram per kilogram of intracoronary bolus eptifibatide by interval of 10 minutes and then stent is embeded. Intervention 3: Intervention group:Group 3: Patients who receive 6 mg of intra-coronary reptal after thrombosis, and then inserted into the stent. Intervention 4: Intervention group: Group 4:Patients after thrombosuction will receive 180 microgram per kilogram of intravenous bolus eptifibatide and then receive 2 microgram per kilogram per minute of infusion over 18 hours. Undecided - It is not yet known if there will be a plan to make this available
public Mostafa Zadkamali
the old building of the School of Public Health,opposite the 17th Shahrivar Hospital,, Namjoo Ave, Shahid Siadati Ave,Rasht
Rasht Iran (Islamic Republic of) 41446-66949 +98 13 3333 6394 mzadkamali@gums.ac.ir Rasht University of Medical Sciences scientific Mostafa Zadkamali
Next to Gilan Province Management and Planning Organization, 15 khordad Ave, Rasht
Rasht Iran (Islamic Republic of) 41939-55588 +98 13 3366 9064 mzadkamali@gums.ac.ir Rasht University of Medical Sciences Iran (Islamic Republic of) ischemic tipic chest pain extending more than 30 min, STelevation more than 1 mm in at least 2 leads with the same name, all patients with STEMI candidate for primary PCI, myocardial infarction not extending more than 12 hours, having life expectancy not less than 6 months, consent for participation in the study, age 18 to 80 years, no evidence for prior myocardial infarction, not having contraindications for reteplase or eptifibatide, not having left bundle branch block, not using GPIIb/IIIa in recent two weeks. 18 years 80 years Both rescue PCI after thrombolytic therapy, emergency CABG, cardiogenic shock, atrial fibrillation TIMI flow grade 3 in primary angiography(ie, having normal blood flow in coronary arteries) simultaneously presence in another intervention study 121 Acute myocardial infarction Treatment - Drugs Treatment - Drugs Treatment - Drugs Treatment - Drugs Intervention group: Group 1: Patients who have a stent after thrombosuction. Intervention group:Group 2: Patients who receive 180 microgram per kilogram of intracoronary bolus eptifibatide by interval of 10 minutes and then stent is embeded. Intervention group:Group 3: Patients who receive 6 mg of intra-coronary reptal after thrombosis, and then inserted into the stent. Intervention group: Group 4:Patients after thrombosuction will receive 180 microgram per kilogram of intravenous bolus eptifibatide and then receive 2 microgram per kilogram per minute of infusion over 18 hours. Coronary blood flow. Timepoint: before and after primary PCI. Method of measurement: based on angiographic scale TIMI blush grade. Left ventricular diastolic dysfunction change. Timepoint: before and after angiography. Method of measurement: according to echocardiographic criteria. ST resolution average. Timepoint: before and 90 minutes after PCI. Method of measurement: based on electrocardiogram. Average of EF changes. Timepoint: before and 3 to 4 days after angioplasty. Method of measurement: based on echocardiography. Rasht University of Medical Sciences Approved 2017-11-04 Ethics committee of Guilan University of Medical Sciences the old building of the School of Public Health ,opposite the 17th Shahrivar Hospital, Shahid Siadati Ave,Namjoo Ave ,Rasht Town Rasht Guilan Iran (Islamic Republic of)