IRCT20101209005352N4 IRCT 2021-02-18 Zanjan University of Medical Sciences Melatonin add on anti epileptic drug Evaluation of efficacy of Melatonin add on routine anti-epileptic drug regimen versus placebo in adult epileptic patients 2017-10-17 anticipated 60 Complete https://irct.ir/trial/27771 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Randomization description: Patients will be randomly assigned to the melatonin and placebo groups with a 1:1 ratio. The blocking method will be used to randomize the allocation of samples. To do this, a computer coding system is used. Each patient will be assigned a random 6-digit code, which will be associated with the same code on a bottle of drug. Only the nurse who fills the bottles will know the contents and the relevant code. This nurse will have no other role in the study. The placebo and melatonin pill will look the same, Blinding description: All patients and physicians and all personnel involved in the data collection process will be unaware of the medicinal nature of the containers. 3 seizure. Intervention 1: Intervention group: Melatonin (patients prescribed 3mg melatonin tablet (add-on valproate) single dose daily, 1 hour before bedtime and continued for 8 weeks.). Intervention 2: Control group: Placebo (patients prescribed placebo tablet (add-on valproate) single dose daily, 1 hour before bedtime and continued for 8 weeks.). Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is No decision has been made until the final analysis of the data and the determination of the results.