IRCT20171004036562N2 IRCT 2020-06-11 Tehran University of Medical Sciences Assessment of laser effect in treatment of women with vuluvaginal atrophy Assessment of fractional co2 laser effect in treatment of women with vuluvaginal atrophy in Emam Khomeini hospital 2017-06-22 anticipated 35 Complete https://irct.ir/trial/27829 interventional Randomization: N/A, Blinding: Not blinded, Placebo: Not used, Assignment: Single, Purpose: Treatment. N/A Atrophy of the vagina. Intervention group: The intervention group uses fractional carbon dioxide laser, which is used in 3 sessions and 4 weeks apart.. No - There is not a plan to make this available Justification or reason for not sharing IPD is Principles of confidentiality and non-disclosure of participants' identities

public Dr. Safa Al-Asiri

Tehran - Tehransar - Laleh Blvd. - North Badakhshan St. - Shahid Hasheminejad Town - Block D6 Unit 16

Tehran Iran (Islamic Republic of) 1387938792 +98 21 4459 8320 safaalasiri99@gmail Tehran University of Medical Sciences scientific Dr. Safa Al-Asiri

Tehran - Tehransar - Laleh Blvd. - North Badakhshan St. - Shahid Hasheminejad Town - Block D6 Unit 16

Tehran Iran (Islamic Republic of) 1387938792 +98 21 4459 8320 safaalasiri99@gmail Tehran University of Medical Sciences Iran (Islamic Republic of) one or more symptoms of VVA (e.g., vaginal discharge, itching, dyspareunia, dryness and urge urinary incontinence). no menstruation for ≥ 12 months. not using local or systemic estrogen therapy. wishing to be sexual active. 45 years no limit Female : use of hormone replacement therapy (systemic or local) up to 6 month before entry to the study. pelvic organ prolapse stage > 2 (according to POP-Q system). active genital infections. acute or recurrent urinary tract infection. use of any vaginal lubricants. moisturizers or local preparations within 30 days before entry to the study. psychiatric disorders which could interfere with informed consent. any chronic disease that could interfere with study compliance. abnormal uterine bleeding which has no exact diagnosis. malignancies of urogenital. N95.2 Postmenopausal atrophic vaginitis Treatment - Devices Intervention group: The intervention group uses fractional carbon dioxide laser, which is used in 3 sessions and 4 weeks apart. The percentage of women who have vaginal dryness. Timepoint: The time intervals for assessing the vaginal dryness before the start of the laser and then one month two months and three months and one year after the laser is done. Method of measurement: questionnaire. Percentage of women who have urinary incontinence. Timepoint: The time intervals for assessing the vaginal dryness before the start of the laser and then one month two months and three months and one year after the laser is done. Method of measurement: questionnaire. Dysuria together. Timepoint: The time intervals for assessing the vaginal dryness before the start of the laser and then one month two months and three months and one year after the laser is done. Method of measurement: questionnaire. Vaginal itching accompanied. Timepoint: The time intervals for assessing the vaginal dryness before the start of the laser and then one month two months and three months and one year after the laser is done. Method of measurement: questionnaire. Vaginal discharge accompanied. Timepoint: The time intervals for assessing the vaginal dryness before the start of the laser and then one month two months and three months and one year after the laser is done. Method of measurement: questionnaire. Dyspareunia. Timepoint: The time intervals for assessing the vaginal dryness before the start of the laser and then one month two months and three months and one year after the laser is done. Method of measurement: questionnaire. Tehran University of Medical Sciences Approved 2017-06-09 Ethics Committee of Tehran University of Medical Sciences Quds St., Poursina St., Tehran University of Medical Sciences Tehran Tehran Iran (Islamic Republic of)