IRCT20121204011662N11 IRCT 2018-01-09 Shiraz University of Medical Sciences Survey of the effect of the intravenous lidocaine during mastectomy on post operative pain and immune response. The effect of perioperative intravenous lidocaine in modified radical mastectomy on postoperative pain and immune function 2017-12-22 anticipated 50 Complete https://irct.ir/trial/28107 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Randomization description: Simple Randomization, Blinding description: For blindness, All of the drugs solution( lidocaine and normal saline) of this study will be prepared in 50 ml syringes that are equal in shape by only person who aware of study's groups .Anesthesiologist, patients all collaborate study's persons will not aware of patients group. N/A Postoperative pain and Immune response. Intervention 1: Intervention group: 20 min before general anesthesia, patients received 2mg/Kg bolus dose of lidocaine then intravenous infusion(1.5 mg/Kg) of lidocaine with infusion pump will be started till end of operation. Intervention 2: Control group: In this group 20 minutes before general anesthesia, patients received 2ml /Kg bolus dose of the physiologic saline then intravenous infusion(1.5 ml/Kg/hr) of the physiologic saline with infusion pump will be started till end of operation. Undecided - It is not yet known if there will be a plan to make this available