IRCT20090317001774N8 IRCT 2018-02-20 Kerman University of Medical Sciences Evaluation of gel and aqueous extract of citrullus Colocynthis in patients with type 2 diabetes Evaluation of the efficacy of gel and aqueous extract of Citrullus colocynthis (L.) Schrad in patients with type 2 diabetes compared to placebo gel 2018-01-10 anticipated 84 Complete https://irct.ir/trial/28336 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Randomization description: After obtaining patient's consent, the patients were classified into three groups according to inclusions criteria for study and balanced block randomization with triplex blocks. In one group, the appropriate amount of formulated gel in carboxymethyl cellulose (5%) is rubbed on the forearm with area 20 cm2 per day for 30 min. In the second group, the aqueous extract is used in a traditional method and the third group receives the placebo, Blinding description: For blinded-experiment, the groups are classified by the Research Center's expert that is not involved in the implementation of the project. This category preserved in the dark package envelope until the end of the design and final analysis at the research center. According to the traditional method group, there is no possibility of blindness for the physician and the patient, but the statistician is blind to the groups. 2-3 Type 2 diabetes mellitus. Intervention 1: Intervention group: The appropriate amount of formulated gel in carboxymethyl cellulose (5%) is rubbed on the forearm with area 20 cm2 per day for 30 min. Intervention 2: Intervention group: Use of aqueous extract in a traditional method. Intervention 3: Control group: Getting a Placebo. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is Decision after the completing of study