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IRCT20130518013364N6 IRCT 2018-02-20 Shahid Beheshti University of Medical Sciences Comparison of dextrose and hyaluronic acid in the treatment of pain in osteoarthritis of the knee Periarticular hypertonic dextrose Vs intraarticular hyaluronic acid injections; Comparison of two minimally invasive Techniques in the treatment of symptomatic knee osteoarthritis 2016-02-09 anticipated 104 Complete https://irct.ir/trial/28337 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: Patients are allocated to two group, using randomized numbers table, Blinding description: The physicians who inject the drug solutions and the ones who evaluate the patients in follow-up visits, are different and are blind to the subject. N/A Gonarthrosis [arthrosis of knee]. Intervention 1: Intervention group: For the HA group, 2.5 mL of hyaluronic acid is injected intraarticulary via the inferomedial of patella. Intervention 2: Intervention group: The HD group, is received 10 ml of 12.5% hypertonic dextrose through four points injection, two points at suprolateral of patella, one point at medial knee joint line and another remained point is at anterior of fibula head, via fan wise technique, 2.5 cc for each point. Yes - There is a plan to make this available What will be shared: Information on the initial and main implications When: Since 2018 To whom: Researchers working in academic institutions Conditions: There are no special conditions Where to obtain: Mehrdad Taheri taheri.1352@yahoo.com How to obtain: Send a request by e-mail Comments:
public Mehrdad Taheri
Shahid Madani street-Imam Hossein Hospital
Tehran Iran (Islamic Republic of) 1617763141 +98 21 7343 0000 m.taheri@sbmu.ac.ir Shahid Beheshti University of Medical Sciences scientific Mehrdad Taheri
Shahid Madani street-Imam Hossein Hospital
Tehran Iran (Islamic Republic of) 1617763141 +98 21 7343 0000 m.taheri@sbmu.ac.ir Shahid Beheshti University of Medical Sciences Iran (Islamic Republic of) Patients with chronic osteoarthritis Grade 2 or higher of OA in radiology Age over 50 years Morning stiffness less than 30 minutes 3 month unresponsiveness to conservative therapy 50 years 75 years Both Severe underlying diseases like diabetes and/or hypothyroidism, immune suppression or deficiency Serious local infectious or inflammatory knee disease Anticoagulant drug history during three last months History of corticosteroid therapy in past year History of prolotherapy in past year History of intraarticular injection in past year Indication for surgical arthroplasty M17.0 Primary gonarthrosis, bilateral Treatment - Other Treatment - Other Intervention group: For the HA group, 2.5 mL of hyaluronic acid is injected intraarticulary via the inferomedial of patella. Intervention group: The HD group, is received 10 ml of 12.5% hypertonic dextrose through four points injection, two points at suprolateral of patella, one point at medial knee joint line and another remained point is at anterior of fibula head, via fan wise technique, 2.5 cc for each point. Pain. Timepoint: 3 months. Method of measurement: VAS. WOMAC Index. Timepoint: 3 months. Method of measurement: The Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC). Shahid Beheshti University of Medical Sciences Approved 2016-02-07 Ethics committee of Shahid Beheshti University of Medical Sciences Shahid Abbas Arabi Street, Yemen Street, Shahid Chamran highway Tehran Tehran Iran (Islamic Republic of)