IRCT20171224038046N1 IRCT 2018-04-05 Research deputy of Shahid Beheshti Medical Science The Comparison of the efficacy of once injection of pneumococcal vaccination versus two times injection in hemodialysis patients The comparison of anti-pneumococcal antibody titer in pneumococcal conjugate 13 valent with polysaccharide 23 valent vaccination versus pneumococcal polysaccharide 23 valent vaccination alone in hemodialysis patients 2017-06-22 anticipated 50 Complete https://irct.ir/trial/28507 interventional Randomization: Not randomized, Blinding: Single blinded, Placebo: Not used, Assignment: Parallel, Purpose: Prevention, Blinding description: The main researcher of the project is not informed about the allocation of the groups, so that the vaccines are provided to clinical care and divided into two groups based on the randomization of the participants in the project. Clinical care is aware of the allocation of the groups for following up the side effects. The participants in the plan will be informed which group is located in. 2-3 Pneumonia. Intervention 1: Intervention group: 25 patients received 13 valent anti pneumococcal vaccine, after 8 weeks received 23 valent vaccine. Intervention 2: Control group: 25 patients receive 23 valent vaccine. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is At the final stages of the project will be identified.