]>
IRCT20180102038182N1 IRCT 2018-01-06 Vice Chancellor for Research and Technology of Ahvaz Jundishapur University of Medical Sciences Platelet derived growth factor and IVF Failure Effects of platelet derived growth factor on Invitro Fertilization Failure 2018-01-21 anticipated 80 Complete https://irct.ir/trial/28658 interventional Randomization: Randomized, Blinding: Single blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: Permuted Block Randomization (Fourth block), Blinding description: This is one blinded study. People who are evaluated, and data analyzer are unaware about the type of groups . 2 Infertile women. Intervention 1: Intervention group: Before PRP therapy and embryo transfer process, standard hormone replacement therapy (HRT) with Estradiol valerate was performed for all patients to endometrial thickness preparation. After sonographic assessment of endometrial thickness, PRP was injected to all patients whether they had appropriate endometrial thickness (7-10mm) or not (< 7mm). Intrauterine infusion of PRP was performed 48 h before embryo transfer in those who had appropriate endometrial thickness; while re-injections of PRP are needed for patients who had not an appropriate endometrial thickness. After sonographic reassessment, embryo transfer process was done through in vitro fertilization (IVF). Eventually, consequences of fertility, embryo implantation and pregnancy maintenance were evaluated. Intervention 2: Control group: Before embryo transfer process, standard hormone replacement therapy (HRT) with Estradiol valerate was performed for all patients to endometrial thickness preparation. After sonographic reassessment, embryo transfer process was done through in vitro fertilization (IVF). Eventually, consequences of fertility, embryo implantation and pregnancy maintenance were evaluated. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is It is not yet known if there will be a plan to make this available
public Razieh Pazhouhan far
بیمارستان امام خمینی، بلوار آزادگان
اهواز Iran (Islamic Republic of) 1234587659 +98 61 3221 6104 razi59h@yahoo.com Ahvaz University of Medical Sciences scientific Mahvash Zargar
Azadegan blv, Imam hospital
Ahvaz Iran (Islamic Republic of) 1234587659 +98 61 3221 6104 zargar-m@ajums.ac.ir Ahvaz University of Medical Sciences Iran (Islamic Republic of) Women less than 40 years old Infertile At least one failure in the IVF process 20 years 40 years Female N97 Female infertility Treatment - Drugs Treatment - Other Intervention group: Before PRP therapy and embryo transfer process, standard hormone replacement therapy (HRT) with Estradiol valerate was performed for all patients to endometrial thickness preparation. After sonographic assessment of endometrial thickness, PRP was injected to all patients whether they had appropriate endometrial thickness (7-10mm) or not (< 7mm). Intrauterine infusion of PRP was performed 48 h before embryo transfer in those who had appropriate endometrial thickness; while re-injections of PRP are needed for patients who had not an appropriate endometrial thickness. After sonographic reassessment, embryo transfer process was done through in vitro fertilization (IVF). Eventually, consequences of fertility, embryo implantation and pregnancy maintenance were evaluated. Control group: Before embryo transfer process, standard hormone replacement therapy (HRT) with Estradiol valerate was performed for all patients to endometrial thickness preparation. After sonographic reassessment, embryo transfer process was done through in vitro fertilization (IVF). Eventually, consequences of fertility, embryo implantation and pregnancy maintenance were evaluated. Endometrial thickness. Timepoint: After prescribing estrogen and before administration PRP. Method of measurement: Sonography. Embryo implantation. Timepoint: After IVF. Method of measurement: Sonography. Pregnancy maintenance. Timepoint: After IVF. Method of measurement: Sonography. Vice Chancellor for Research and Technology of Ahvaz Jundishapur University of Medical Sciences Approved 2017-11-28 کمیته اخلاق دانشگاه علوم پزشکی جندی شاپور اهواز Ahvaz Jundishapur University of Medical Sciences, Golestan, Ahvaz Ahvaz Khouzestan Iran (Islamic Republic of)