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IRCT20150427021981N1 IRCT 2018-04-04 Mashhad University of Medical Sciences Ultrasonographic ٍEvaluation of lung Recruitability in Acute Respiratory Distress Syndrome Evaluation of Ultrasonographic lung Recruitibility with Two Types of Positive End Expiratory Pressure Selection in Moderate to Severe Acute Respiratory Distress Syndrome 2018-01-21 anticipated 15 Complete https://irct.ir/trial/28738 interventional Randomization: N/A, Blinding: Not blinded, Placebo: Not used, Assignment: Single, Purpose: Supportive, Other design features: This study is quasi-experimental with "before-after" design. N/A Acute Respiratory Distress Syndrome. Intervention and control group: Use of positive end expiratory pressure according to"low PEEP table" in ARDS net protocol during mechanical ventilation (control group) and then (after 30 minutes), Use of positive end expiratory pressure according to recommended level in "Express trial" in the same patient (intervention group). Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is There is no further information
public Ahmad bagheri moghaddam
No.187, yasaman 6 Ave, sajjad Blvd
Mashhad Iran (Islamic Republic of) 9186684736 +98 51 3760 6328 bagheriA@mums.ac.ir Mashhad University of Medical Sciences scientific Ahmad bagheri moghaddam
No.187,Yasaman 6 Ave, Sajjad Blvd
Mashhad Iran (Islamic Republic of) 9186684736 +98 51 3760 6328 bagheriA@mums.ac.ir Mashhad University of Medical Sciences Iran (Islamic Republic of) Patients with Moderate to Severe Acute Respiratory Distress Syndrome and under invasive mechanical ventilation 18 years no limit Both Younger than 18 year Less than 24 h or more than 96 h after the onset of the disease. Unstable hemodynamic Contraindication for using of high PEEP Known heart failure Acute ischemic heart disease or uncontrolled arrythmia Chronic lung disease BMI>40 J80 Acute respiratory distress syndrome Treatment - Other Intervention and control group: Use of positive end expiratory pressure according to"low PEEP table" in ARDS net protocol during mechanical ventilation (control group) and then (after 30 minutes), Use of positive end expiratory pressure according to recommended level in "Express trial" in the same patient (intervention group) Lung recruitability (Reaeration) with two type of positive end expiratory pressure selection. Timepoint: Initial measurement of lung recruitment (Reaeration) with a low level of positive end expiratory pressure (low PEEP table) and after 30 minutes with a high positive end expiratory pressure level (Express trial). Method of measurement: By lung ultrasonography with 2.5 to 5 megahertz curve probe. Oxygenation state. Timepoint: Five minutes after positive end expiratory pressure (PEEP) change. Method of measurement: Dividing the arterial oxygen pressure to the fraction of inspired oxygen (Po2/Fio2 ratio). Mashhad University of Medical Sciences Approved 2017-07-09 Ethic committee of mashhad university of medical sciences ghoreishi building,daneshgah street,Mashhad Mashhad Razavi Khorasan Iran (Islamic Republic of)