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IRCT20121208011689N6 IRCT 2018-09-30 Tabriz University of Medical Sciences Effect of Curcumin in treatment of diabetic complications Effect of curcumin supplementation on serum levels of advanced glycation end products , tumor necrosis factor alpha and metabolic indices in patients with diabetic retinopathy 2017-03-21 anticipated 50 Complete https://irct.ir/trial/28777 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Randomization description: The eligible participants will be randomly allocated to intervention and placebo groups using a software generated random blocks. The generated random sequence will be administered by an independent third party who is blind to the trial throughout the study, Blinding description: In this double-blind study, patient and investigator will not be aware of the treatment assignments for the duration of the study. For blinding the trial, the curcumin capsules and placebo, will be identical in appearance, packaging, and labeling. All capsules will be packed and encoded by the company. 3 People with diabetic retinopathy. Intervention 1: Intervention group: Patients in this group will receive curcumin capsule for 8 weeks. curcumin capsule is used once a day with lunch. Intervention 2: Control group:Patients in this group will receive placebo capsules for 8 weeks which are same size and shape and used once a day with lunch. Yes - There is a plan to make this available What will be shared: Part of data about primary consequnece When: Six month after results published To whom: Researcher who are working in university institutes Conditions: Only for meta-analysis studies data will be available to other researchers. Where to obtain: By my gmail n.radkhah@gmail.com How to obtain: As soon as possible Comments:
public Nima Radkhah
Daneshgah Street
Tabriz Iran (Islamic Republic of) 5136782465 +98 41 3335 0914 N.radkhah@gmail.com Tabriz University of Medical Sciences scientific Nima Radkhah
Daneshgah Street
Tabriz Iran (Islamic Republic of) 5136782465 +98 41 3335 0914 N.radkhah@gmail.com Tabriz University of Medical Sciences Iran (Islamic Republic of) Desire to cooperate and sign informed consent form after full knowledge of the goals and method of implementation of the study Age between 40 to 70 years old People with diabetic retinopathy without insulin 40 years 70 years Both Receiving insulin Cases of chronic diseases such as cardiovascular, renal and hepatic disorders Malabsorption syndrome and inflammatory bowel disease (Crohn's disease, celiac sproctomy, short stomach and biliary tract jejuni-ileal syndrome) Having certain physiological conditions like pregnancy and breastfeeding H36.0 Diabetic retinopathy Treatment - Drugs Placebo Intervention group: Patients in this group will receive curcumin capsule for 8 weeks. curcumin capsule is used once a day with lunch. Control group:Patients in this group will receive placebo capsules for 8 weeks which are same size and shape and used once a day with lunch. Serum level of methylglyoxal. Timepoint: First of study and in the end of study. Method of measurement: Elisa. Serum levels of Pentosidine. Timepoint: At the beginning of the study and 8 weeks later. Method of measurement: Elisa. Serum level of Carboxymehtyllyzine. Timepoint: At the beginning of the study and 8 weeks later. Method of measurement: Elisa. Serum level of tumor necrosis factor alpha. Timepoint: At the beginning of the study and 8 weeks later. Method of measurement: Elisa. Tabriz University of Medical Sciences Approved 2018-06-11 Tabriz University of Medical Sience Daneshgah Ave Tabriz East Azarbaijan Iran (Islamic Republic of)