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IRCT138811061162N15 IRCT 2011-01-26 Mashhad university of medical sciences Prophylactic effect of clofibrate on prevention of jaundice in very low birth weight twin pregnancy neonates Prophylactic effect of clofibrate on prevention of jaundice in very low birth weight twin pregnancy neonates 2010-09-25 anticipated 50 Complete https://irct.ir/trial/288 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Supportive. 3 Very low birth weight hyperbilirubinemia. Intervention 1: Intervention group: 100 mg of clofibrate. Intervention 2: Control group: sterile water.
public Dr. Ashraf Mohammadzadeh
NRC-NICU-Emamreza hospital
Mashhad Iran (Islamic Republic of) 9137913316 +98 51 1852 1121 mohamadzadeha@mums.ac.ir Neonatal Research Center scientific Dr.Ashraf Mohammadzadeh
NRC-NICU-Emaereza hospital
Mashhad Iran (Islamic Republic of) 9137913316 +98 51 1852 1121 mohamadzadeha@mums.ac.ir Neonatal Research Center Iran (Islamic Republic of) Inclusion criteria: twin pregnancy with same gender very low birth weight neonates who are admitted to NICU of Emamreza Hospital. These neonates are healthy, with birth weight equal or less than 1500 grams. Exclusion criteria: Babies with hemolysis, excessive external bleeding, G6PD, sepsis, infection, severe respiratory disease need to ventilation, congenital anomalies and metabolic diseases are excluded 1 year 2 years Both P07.1 Other low birth weight Prevention Placebo Intervention group: 100 mg of clofibrate Control group: sterile water Serum bilirubin. Timepoint: befor intervention,24,48,72 and 96 hours after intervention. Method of measurement: measurement of serum bilirubin (diazo method). Jaundice. Timepoint: before intervention,24,48,72 and 96 hours after intervention. Method of measurement: observation. Mashhad university of medical sciences Approved 2010-09-25 Vice chancellor for research of Mashhad University of medical sciences Ghoreshi building, Daneshgah street Mashhad Iran (Islamic Republic of)