IRCT20160401027165N1 IRCT 2018-01-13 Shahid Beheshti University of Medical Sciences The role of dexmedethomidine in sedation and analgesia in the emergency department ندارد Comparison of the combination of dexmedethomidine and fentanyl with midazolam and fentanyl in induction of sedation and analgesia for reduction of distal radial fracture in the emergency department 2014-04-22 anticipated 40 Complete https://irct.ir/trial/28861 interventional Randomization: Randomized, Blinding: Single blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Other design features: does not have, Randomization description: ُSimple Randomization, Blinding description: In this study, the researcher and clinical caregiver (professor and assistant) were not blinded due to the difference in method of each drug administration and also the need for knowledge about the type of administrating drug to deal with their possible side effects and complication, But the outcome elevator (the second senior assistant) and the data analyzer were unaware of the study. 2-3 distal radial fracture. Intervention 1: Intervention group: the first group, in this group midazolam (Darupakhsh Co, Iran) was given with dose of 0.1 mg /kg, and Fentanyl (Abu Rayhan CO, Iran),with dose of 3 μg/kg with with titarting dose until reaching the Ramsey sedation scale 5 . Intervention 2: Intervention group: The second group, in this group, dexmedethomidine (Huspiria of USA, Behestan Daroba) was given with a dose of 1 mg/kg with 10-minute intravenous infusion and fetanyl(Abu Ravihan Co, Iran) with a dose of 3 μg/kg with titrated dose until reaching to a Ramsey sedation scale of 5. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is No more information