IRCT20180116038386N1 IRCT 2018-04-21 Abadan University of Medical Sciences Effect of umbilical cord Wharton's jelly in treatment of melasma Effect of umbilical cord Wharton's jelly on mother‘s melasma 2018-02-20 anticipated 25 Complete https://irct.ir/trial/29005 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: Method of randomization will be simple. Unit of randomization will be individual. Tools of randomization will be random number table. Person randomising the patient does not know what the next treatment allocation will be, Blinding description: For elimination of the possibility of any probable bias due to the knowledge of patients and investigators about the type of treatment we will perform a double blind study. The patients and investigators were blinded to treatment type (Wharton's Jelly or base of cream). placebo (base of cream) will be similar to Wharton jelly in figure, color and volume. Wharton's Jelly or base of cream is used on face of patients topically by a educated person. 0 (exploratory trials) Melasma. Intervention 1: Intervention group: A part of umbilical cord (10 cm) will be cut immediately after parturition and will be washed in sterile plate using sterile normal saline. Warthon Jelly will be extracted using a razor blade. Extracted warthon jelly will be used on hyperpigmentation area of mothers face topically. This intervention will be single dose. Intervention 2: Control group: Base of cream. single dose. Yes - There is a plan to make this available What will be shared: All of data will be shared. When: One month after publishing data To whom: Researcher in each field Conditions: Use in therapy Where to obtain: Authors of article How to obtain: Almost one month Comments: